URTICA PILULIFERA UPREGULATES THE EXPRESSION OF HEAT SHOCK PROTEIN (HSP70) IN KIDNEYS OF DIABETIC RATS

  • Ahed J Alkhatib Jordan university of Science and Technology, Jordan
  • Fatima Laiche Al-albayt University, Jordan
  • Mosleh A Alkhatatbeh Jordan University of Science and Technology
  • Saleh A. Alrasheidi University of Arkansas, USA
  • Murtala Muhammad Jordan university of Science and Technology, Jordan
  • ALiyu Maje Bello Jordan university of Science and Technology, Jordan
  • Ibrahim Ahmad Muhammad Jordan university of Science and Technology, Jordan
  • Ya'u Sabo Ajingi Jordan university of Science and Technology, Jordan
  • Mustapha Garba Muhammad Jordan university of Science and Technology, Jordan
  • Aminu Faruk Kabara Jordan university of Science and Technology, Jordan

Abstract

U. pilulifera has been used by people to treat various diseases including diabetes. There is a need to study cellular mechanisms associated with U. pilulifera. The purpose of the present study was to study the effects of the extract of U. pilulifera on the expression of HSP70 in the kidneys of diabetic rats. U. pilulifera was collected from various places in Jordan, air dried and extracted by Soxhlet cold extractor using absolute methanol as solvent and remained for three consecutive days. Extracted juice was kept in refrigerator at 4°C. Diabetes was induced through administration of alloxan 150 mg/kg body weight intraperitoneally. Study model included 4 groups: control group, diabetic group, diabetic group treated with 1.25 mg/kg body weight, and diabetic group treated with 1.88 mg/kg body weight. Study findings showed that diabetes lowered the expression of HSP70 significantly (P 0.000) compared with control group in kidneys. Treatment with either dose of U. pilulifera increased the expression of HSP70 significantly in kidney tissue. Taken together, diabetic patients can benefit from U. pilulifera to cope with oxidative stress attributed to diabetes.

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Published
2014-07-30
How to Cite
Alkhatib, A. J., Laiche, F., Alkhatatbeh, M. A., Alrasheidi, S. A., Muhammad, M., Bello, A. M., Muhammad, I. A., Ajingi, Y. S., Muhammad, M. G., & Kabara, A. F. (2014). URTICA PILULIFERA UPREGULATES THE EXPRESSION OF HEAT SHOCK PROTEIN (HSP70) IN KIDNEYS OF DIABETIC RATS. European Scientific Journal, ESJ, 10(21). https://doi.org/10.19044/esj.2014.v10n21p%p

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