@article{Joël_Marcel_Kangah Mireille_Yvette_Sanogo_Claire Chiyae_Koffi Mathieu_2021, title={Assessment of Radical Scavenging and Sickling Inhibitory Activities of the Bark of Disthemonanthus Benthamianus (Caesalpiniaceae)}, volume={17}, url={https://eujournal.org/index.php/esj/article/view/14130}, DOI={10.19044/esj.2021.v17n10p121}, abstractNote={<p>Among the medicinal plants used in the treatment of sickle cell disease in south-east of Côte d’Ivoire is Disthemonanthus benthamianus. This paper focuses on assessing its antioxidant properties and its antisickling activity. The test of inhibition of sodium metabisulfite-induced sickling of the erythrocytes was carried out based on this evaluation. The total phenolic compounds contents were 45 ± 0.64 and 39.84 ± 0.69 mg/g of dry weight for ethanolic extract and the decocted respectively. The DPPH reduction test showed that the decocted (9 μg/mL) had a lower IC50 than the ethanolic extract (16 μg/mL). There was no significant difference between the sickling inhibitory activities of the ethanolic extract (87.00%) and the decocted (81.66%). This study showed that both extracts had sickling inhibitory and antioxidant activities.</p&gt;}, number={10}, journal={European Scientific Journal, ESJ}, author={Joël, Akakpo-Akue and Marcel, Ahon Gnamien and Kangah Mireille , Kplé Tatiana and Yvette, Fofié and Sanogo, Ibrahime and Claire Chiyae, Yapo-Crezoit Antoinette and Koffi Mathieu, Kra Adou}, year={2021}, month={Mar.}, pages={121} }