Fluoxetine Inhibits Calcium Influx in MIN6 cells

  • Ahmed S. Hisab Medical School, University of Nottingham, Nottingham, UK

Abstract

Fluoxetine, a widely used antidepressant that primarily acts as a selective serotonin reuptake inhibitor, inhibits various membrane receptors and Ca 2+ influx by unknown mechanism. In addition, it has been shown that Ca2+ is control mitochondrial metabolism and respiration. Here, effect of fluoxetine on the voltage gated Calcium channels in MIN6 cells was examined. Using Ca 2+ imaging is to assess intracellular calcium. Fluoxetine 30 µM inhibited ca 2+ levels. These results indicated a tighter binding of fluoxetine to the Calcium than to the resting state of other channels, suggesting a more potent inhibition of Ca 2+ channels at physiological resting membrane potential. Altogether, these data demonstrate that clinically relevant concentrations of fluoxetine exert a voltage-dependent block of channels that may contribute to this antidepressant’s pharmacological effects.

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Published
2018-09-30
How to Cite
Hisab, A. S. (2018). Fluoxetine Inhibits Calcium Influx in MIN6 cells. European Scientific Journal, ESJ, 14(27), 10. https://doi.org/10.19044/esj.2018.v14n27p10