INHERITED THROMBOPHILIA IN TURKISH WOMEN, AS A RISK FACTOR FOR ISCHEMIC PLACENTAL DISEASES

Abstract

We aim to elucidate the link between inherited thrombophilias andpregnancies complicated with ischemic placental diseases, in Turkishwomen. This is a case control study comprising 140 women with ischemicplacental disease and 60 uncomplicated pregnant women. Parametersincluding haemoglobin, platelet count, uric acid, vitamin B12, folic acid,copper, homocysteine, plasminogen activator inhibitor-1, fibrinogen, proteinS, protein C, activated protein C resistance values were significantly changedin women with ischemic placental disease when compared to those withnormal pregnancies.The association between thrombophilia and ischemic pregnancy diseases isstronger than suggested previously. Furthermore, copper is selectivelyelevated in complicated pregnancies.