Assessment of Tumor markers, C-reactive Protein, Cortisol and Total Plasma Peroxides Levels in Uterine Leiomyoma Patients

  • Moses Akiibinu Department of Biochemistry and Chemistry, Caleb University Lagos, Nigeria
  • Adebayo Amballi Department of Chemical Pathology and Immunology, Olabisi Onabanjo University, Sagamu, Ogun state, Nigeria
  • Olusoji Jagun Department of Obstetrics and Gynaecology, Olabisi Onabanjo University, Sagamu, Ogun state, Nigeria.
  • Ajibola Adisa Clinical Chemistry Department, Midland Regional Hospital, Mullingar, Republic of Ireland.
  • Susan Akiibinu Clinical Nursing Department, University College Hospital, Ibadan, Nigeria
  • Adeolu Amusan Department of Chemical Pathology and Immunology, Olabisi Onabanjo University, Sagamu, Ogun state, Nigeria
  • Ibukun Jimo Department of Biochemistry and Chemistry, Caleb University Lagos, Nigeria.
  • Ayodele Olalekan Chemical Pathology Department, University College Hospital, Ibadan, Nigeria

Abstract

Objective: The pathophysiology of uterine leiomyoma is yet to be fully understood. This study determined the status of cortisol, C-reactive protein, total plasma peroxide and selected tumor markers in uterine leiomyoma patients. Materials and Methods: Forty-eight individuals (aged 25-45 years) with uterine leiomyoma (nodules=1-4; size=5-120mm) were recruited for this study. Forty apparently age-matched normal individuals without uterine leiomyoma served as controls. The patients and controls were selected after confirmation of the status of uterine leiomyoma by ultrasound imaging technique. The plasma levels of total plasma peroxides(TPP), cortisol, carcino-embryonic antigen(CEA), alpha fetoprotein (AFP), carbohydrate antigen 125(CA125) and C-reactive protein(CRP) were determined in them using spectrophotometry, enzyme linked immunosorbent assay and single radial immunodiffusion (Maccini) methods respectively. Results: The result shows significantly higher levels of TPP (p0.05) changes in the plasma levels of cortisol, CEA and AFP in the leiomyoma patients when compared with the controls. Significant (r=0.521, p=0.03) correlation existed between the number of myoma nodules and the levels of CRP in the leiomyoma patients. The size of the nodules correlated significantly (r=0.47, p=0.04) with the plasma levels of TPP. Conclusion: Elevated levels of CRP and TPP could indicate oxidative stress and inflammatory response in uterine leiomyoma patients. The induced inflammation and oxidative stress may increase with increase in number and size of the myoma nodules respectively. Higher level of CA125 could be a feature of uterine leiomyoma.

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Published
2017-03-31
How to Cite
Akiibinu, M., Amballi, A., Jagun, O., Adisa, A., Akiibinu, S., Amusan, A., Jimo, I., & Olalekan, A. (2017). Assessment of Tumor markers, C-reactive Protein, Cortisol and Total Plasma Peroxides Levels in Uterine Leiomyoma Patients. European Scientific Journal, ESJ, 13(9), 333. https://doi.org/10.19044/esj.2017.v13n9p333