Synthesis and Evaluation of Antioxidant Activity of Some New Heterocyclic Compounds Bearing the Benzo[B]Furan Moiety

  • Marwa Abdel-motaal Department of chemistry, faculty of science, Mansoura University, Mansoura, Egypt
  • E. M. Kandeel Department of chemistry, faculty of science, Mansoura University, Mansoura, Egypt
  • M. Abou-Elzahab Department of chemistry, faculty of science, Mansoura University, Mansoura, Egypt
  • F. Elghareeb Department of chemistry, faculty of science, Mansoura University, Mansoura, Egypt

Abstract

New compounds were synthesized by the reaction of 3-acetyl-5- methoxy-2-methylbenzofuran (1) with cyanoacetylhydrazine which afforded the hydrazide hydrazone derivative 2. Compound 2 underwent a series of heterocyclization reactions to give the new pyrazole, isoxazole, cyclopentanothiophene, thiazole, triazole, 2H-chromene and pyridone derivatives (3-13). The elemental and spectral data (IR, 1H NMR and MS) characterized their structures. Screening for some selected compounds was carried for their potential antioxidant activities using ABTS. Among the tested samples compounds 9, 11, 5 and 10 exhibited promising activity.

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Published
2017-10-31
How to Cite
Abdel-motaal, M., Kandeel, E. M., Abou-Elzahab, M., & Elghareeb, F. (2017). Synthesis and Evaluation of Antioxidant Activity of Some New Heterocyclic Compounds Bearing the Benzo[B]Furan Moiety. European Scientific Journal, ESJ, 13(30), 297. https://doi.org/10.19044/esj.2017.v13n30p297