Facteurs prédictifs de décès au cours de la TB pulmonaire chez les PvVIH au CNHU Fann de Dakar

  • Harouna Amadou M.L Service de Maladies infectieuses, Hôpital Régional de Maradi, Faculté des Sciences de la Santé, Université de Maradi, Niger
  • Mahamadou Doutchi Service de Maladies infectieuses et Tropicales, Hôpital National de Zinder, Faculté des Sciences de la Santé, Université de Zinder, Niger
  • Ousmane Abdoulaye Laboratoire CHR de Maradi, Université de Maradi, Niger
  • Amadou O. Hôpital Regional de Maradi, Faculté des Sciences de la Santé, Université de Maradi, Niger
  • Abdou Neino M. Hôpital Regional de Maradi, service de Médecine Interne
  • Kadri Sani Hôpital Regional de Maradi, service de Médecine Interne
  • Abdoul Aziz Garba Service de Médecine interne, Hôpital National de Zinder-Niger
  • CT Ndour Service de Maladies infectieuses et Tropicales, CNHU Fann, Faculté des Sciences de la Santé, Université de Dakar

Abstract

Objectives: In sub-Saharan Africa, tuberculosis is the first pulmonary-located opportunistic infection and the leading cause of death among people living with HIV (PLWHA). This paper focuses on studying the predictive factors of death in people co-infected with pulmonary tuberculosis and HIV at the Ibrahima DIOP MAR clinic for infectious and tropical diseases at the CHNU Fann in Dakar. Materials and Methods: This was a retrospective, descriptive, and analytical study conducted from 1st January 1998 to 31st December 2009. It has been of interest to all patients with a successful pulmonary tuberculosis diagnosis and positive HIV status. Epidemiological, clinical, para-clinical, and progressive parameters were studied. Results: A total of 665 cases of tuberculosis/HIV co-infection were observed during the study period, of which 207 deaths or lethality (31.37%) was recorded. The average age of patients was 39±9 years with extremes of 5 and 74 years. The average length of hospitalization was 31.67 ± 20.67 with extremes of 4 and 312 days for surviving patients compared to 19.00 ± 16.42 with extremes of 1 to 90 days for deceased patients. Immunosuppression was significantly associated with death (p=0.001) with a median CD4 of 32.50 elts/mm3. Lethality was significantly elevated in the presence of dyspnea (p= 0, 00014), consciousness disorder (p=10-6 ), motor deficit (p= 0.008), and hemoptysis (p= 0.03). Conclusion: Tuberculosis/HIV co-infection is a common association in Africa. Here, we are talking about a deadly duo. Taking it requires a good knowledge of the factors of poor prognosis and a good integration of the two programs.

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Published
2018-12-31
How to Cite
M.L, H. A., Doutchi, M., Abdoulaye, O., O., A., M., A. N., Sani, K., Garba, A. A., & Ndour, C. (2018). Facteurs prédictifs de décès au cours de la TB pulmonaire chez les PvVIH au CNHU Fann de Dakar. European Scientific Journal, ESJ, 14(36), 1. https://doi.org/10.19044/esj.2018.v14n36p1