Hormesis Effect of Radon in Rats of the Krushinsky-Molodkina Line
Keywords:
Radon, Epileptic rats, Oxidative stress, Sulfhydryl groups
Abstract
According to this research, the use of radon inhalation in experimental animals, particularly in genetically determined rats with epileptic seizures, altered all parameters of the epileptic seizure development picture, namely the hidden period and the first and second wild jog duration after the audiogenic signal. On the third day, no response to the audiogenic signal was observed at all, and there was not even a single episode of tonic-clonic seizures. All what was mentioned suggests that radon inhalation can be used to treat epilepsy. This study is the first precedent of attempting R-Ho through inhalation for treatment of epileptic seizures in animal models with further translation to clinical study in humans through pilot phase II study. More profound and scientifically systematized approach is needed to determine the uniqueness of Tskhaltubo water springs, investigating the mechanisms of radon effects on the excitatory and inhibitory functioning of CNS, and the use of further clinical studies to establish its effectiveness on humans.
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References
1. Aguiar, CC., Almeida, AB., Araújo, PV., et al. (2012). Oxidative stress and epilepsy: literature review. Oxid Med Cell Longev.795259. doi:10.1155/2012/795259.
2. Bangasser, DA., & Valentino, RJ. (2014). Sex differences in stress-related psychiatric disorders: neurobiological perspectives. Front Neuroendocrinol. 35:303–19. doi: 10.1016/j.yfrne.2014
3. Bazzigaluppi, A.E. (2017). Hungry Neurons: Metabolic Insights on. international journal of molecular sciences, 28 October 4-5.
4. DiNuzzo, M., Mangia, S., Maraviglia, B., & Giove, F. (2014). Physiological bases of the K+ and the glutamate/GABA hypotheses of epilepsy. Epilepsy Res. 108, 995–1012.
5. Hashemian, M., Anissian, D., Ghasemi-Kasman, M., Akbari, A., Khalili-Fomeshi, M., Ghasemi, S. et al. (2017). Curcumin-loaded chitosan-alginate-STPP nanoparticles ameliorate memory deficits and reduce glial activation in pentylenetetrazol-induced kindling model of epilepsy. Prog Neuropsychopharmacol Biol Psychiatry. 79:462–71.
6. Isaksen, T.J., & Lykke-Hartmann, K. (2016). Insights into the pathology of the α2-Na+/K+-ATPase in neurological disorders; lessons from animal models. Front. Physiol. 7, 161.
7. Gietzen, DW., Ross-Inta, CM., Rudell, JB., Hao, S., & Donovan, M. (2016). Calcium-dependent eukaryotic initiation factor 2α phosphatase complexed with calcineurin restores control to anterior piriform cortex neural circuitry after activation by essential amino acid deficiency. J Nutr Biol; 2:33–44.5,
8. Gelashvili, GK., Vepkhvadze, N., Xazaradze, R., et al. (2001). Current radiation safety issues in Georgia. 1 National Conference. Tbilisi pp 146-156.
9. Jobe, PC., Picchioni, AL., & Chin, L. (1973). Role of norepinephrine in audiogenic seizure in the rat. J. Pharmacol. Exp. Ther. 184, 1-10.
10. Kaplan, D.I., Isom, L.L., & Petrou, S. (2016). Role of sodium channels in epilepsy. Cold Spring Harb. Perspect. Med.
11. Khazaradze, K.R., Khazaradze, R.E., Amiranashvili, A.E., Bliadze, T.A., Nodia, A.B., Nikiforov, G.I., & Chelidze, L.D. (2001). Some results of studies of radon content in the human environment // 1st international conference on ecology and environmental management of the Caucasus / Tbilisi, pp.61-63.
12. Krushinsky, L., Molodkina, L., Fless, D., Dobrokhotova, L., Steshenko, A., Zorina, Z., & Romanova, L. (1970). The functional state of the brain during sonic stimulation. – In: Welch B. and Welch A. (eds.). Physiological effects of noise, New York: Plenum Press, pp.151-158.
13. Lee, Y., Rodriguez, OC., Albanese, C., Santos, VR., Cortes de Oliveira, JA., Donatti, ALF., et al. (2018). Divergent brain changes in two audiogenic rat strains: a voxel-based morphometry and diffusion tensor imaging comparison of the genetically epilepsy prone rat (GEPR-3) and the Wistar Audiogenic Rat (WAR). Neurobiol Dis. 111:80–90. doi: 10.1016/j.nbd.2017.12.014
14. Lomidze, G., Kasradze, S., Kvernadze, D., Okujava, N., Toidze, O., Hanneke, M., de Boer, Tarun Dua, & Josemir W. Sander (2012). The prevalence and treatment gap of epilepsy in Tbilisi, Georgia, Epilepsy Research, Volume 98, Issues 2–3, Pages 123-129, ISSN 0920-1211.
15. Martin, K., Jackson, CF., Levy, RG., Cooper, PN. (2016). Ketogenic diet and other dietary treatments for epilepsy. Cochrane Database Syst Rev ; 2:CD001903
16. Morandi, G., Guido, D., & Tagliabue, A. (2015). A bibliometric study of scientific literature on the dietary therapies for epilepsy in Scopus. Nutr Neurosci;18:201–9.
17. Marshalick, BE., & Fenko, AN. (1991). The use of radon baths for rehabilitating the immune system of patients with bronchial asthma. VoprKurortol Fiziother LechFiz Kult. 1991;6:6–10.
18. Nikolashvili, M., Mchedluri, T., Museliani, T. (2006). Effect of tskaltubo radon mineral waters on aggressive behaviour of animals and distribution of free amino acids in structures if the brain. saq. mecn. Acad. Mmacne, ser. Bboil. A t 32, N1. 119-123.
19. Nikolashvili, M., Nanobashvili, Z., & Mitagvaria, N. (2021). Radon hormesis in epileptic phatogenesis ans predictors of oxidative stress Georgian Medical News, No 4 (313).
20. Pandey, M.K., Mittra, P., & Maheshwari, P.K. (2012). The Lipid Peroxidation Product as a Marker of Oxidative Stress in Epilepsy.
21. Raimondo, J.V., Burman, R.J., Katz, A.A., Akerman, C.J. (2015). Ion dynamics during seizures. Front. Cell. Neurosci., 9, 419.
22. Ryan, MJ., Jackson, JR., Hao, Y., & Leonard, SS., Always, SE. (2011). Inhibition of xanthine oxidase reduces oxidative stress and improves skeletal muscle function in response to electrically stimulated isometric contractions in aged mice. Free Radic Biol Med.; 51(1):38-52. doi:10.1016/j.freeradbiomed.2011.04.002
23. Ross, K.C., & Coleman, J.R. (2000). Developmental and genetic audiogenic seizure models: behavior and biological substrates. Neuroscience and Biobehavioral Reviews, 2000, 24, 639-653
24. Shultz, S.R., O’Brien, T.J., Stefanidou, M., & Kuzniecky, R.I. (2014). Neuroimaging the epileptogenic process. Neurother. J. Am. Soc. Exp. Neurother. 11, 347–357
25. Silva, L.F., Hoffmann, M.S., Rambo, L.M., Ribeiro, L.R., Lima, F.D., Furian, A.F., Oliveira, M.S., Fighera, M.R., & Royes, L.F. (2011). The involvement of Na+/K+-ATPase activity and free radical generation in the susceptibility to pentylenetetrazol-induced seizures after experimental traumatic brain injury. J. Neurol. Sci. , 308, 35–40.
26. Sedlak, J., & Landsay, R. (1968). Biochem. 25, 192-205.
27. Yarmoshenko, IV. (2002). Meta-analysis of 18 radon and lung cancer case control studies. In: Proceedings of the 7th International Symposium, Natural Radiation Environment (NRE VII), Rhodes, May, Elsevier Conf. Series, in press
28. Yuta Shibamoto & Hironobu Nakamura (2018). Overview of Biological, Epidemiological, and Clinical Evidence of Radiation Hormesis. Int J Mol Sci.; 19, (8):2387
29. Zharkinbekova, N.A., & Ormanov, N.Z. (2019). Lipid Peroxidation and the Antioxidant System in the Blood of Epileptic Patients. Neurochem. J. 13, 378–384.
2. Bangasser, DA., & Valentino, RJ. (2014). Sex differences in stress-related psychiatric disorders: neurobiological perspectives. Front Neuroendocrinol. 35:303–19. doi: 10.1016/j.yfrne.2014
3. Bazzigaluppi, A.E. (2017). Hungry Neurons: Metabolic Insights on. international journal of molecular sciences, 28 October 4-5.
4. DiNuzzo, M., Mangia, S., Maraviglia, B., & Giove, F. (2014). Physiological bases of the K+ and the glutamate/GABA hypotheses of epilepsy. Epilepsy Res. 108, 995–1012.
5. Hashemian, M., Anissian, D., Ghasemi-Kasman, M., Akbari, A., Khalili-Fomeshi, M., Ghasemi, S. et al. (2017). Curcumin-loaded chitosan-alginate-STPP nanoparticles ameliorate memory deficits and reduce glial activation in pentylenetetrazol-induced kindling model of epilepsy. Prog Neuropsychopharmacol Biol Psychiatry. 79:462–71.
6. Isaksen, T.J., & Lykke-Hartmann, K. (2016). Insights into the pathology of the α2-Na+/K+-ATPase in neurological disorders; lessons from animal models. Front. Physiol. 7, 161.
7. Gietzen, DW., Ross-Inta, CM., Rudell, JB., Hao, S., & Donovan, M. (2016). Calcium-dependent eukaryotic initiation factor 2α phosphatase complexed with calcineurin restores control to anterior piriform cortex neural circuitry after activation by essential amino acid deficiency. J Nutr Biol; 2:33–44.5,
8. Gelashvili, GK., Vepkhvadze, N., Xazaradze, R., et al. (2001). Current radiation safety issues in Georgia. 1 National Conference. Tbilisi pp 146-156.
9. Jobe, PC., Picchioni, AL., & Chin, L. (1973). Role of norepinephrine in audiogenic seizure in the rat. J. Pharmacol. Exp. Ther. 184, 1-10.
10. Kaplan, D.I., Isom, L.L., & Petrou, S. (2016). Role of sodium channels in epilepsy. Cold Spring Harb. Perspect. Med.
11. Khazaradze, K.R., Khazaradze, R.E., Amiranashvili, A.E., Bliadze, T.A., Nodia, A.B., Nikiforov, G.I., & Chelidze, L.D. (2001). Some results of studies of radon content in the human environment // 1st international conference on ecology and environmental management of the Caucasus / Tbilisi, pp.61-63.
12. Krushinsky, L., Molodkina, L., Fless, D., Dobrokhotova, L., Steshenko, A., Zorina, Z., & Romanova, L. (1970). The functional state of the brain during sonic stimulation. – In: Welch B. and Welch A. (eds.). Physiological effects of noise, New York: Plenum Press, pp.151-158.
13. Lee, Y., Rodriguez, OC., Albanese, C., Santos, VR., Cortes de Oliveira, JA., Donatti, ALF., et al. (2018). Divergent brain changes in two audiogenic rat strains: a voxel-based morphometry and diffusion tensor imaging comparison of the genetically epilepsy prone rat (GEPR-3) and the Wistar Audiogenic Rat (WAR). Neurobiol Dis. 111:80–90. doi: 10.1016/j.nbd.2017.12.014
14. Lomidze, G., Kasradze, S., Kvernadze, D., Okujava, N., Toidze, O., Hanneke, M., de Boer, Tarun Dua, & Josemir W. Sander (2012). The prevalence and treatment gap of epilepsy in Tbilisi, Georgia, Epilepsy Research, Volume 98, Issues 2–3, Pages 123-129, ISSN 0920-1211.
15. Martin, K., Jackson, CF., Levy, RG., Cooper, PN. (2016). Ketogenic diet and other dietary treatments for epilepsy. Cochrane Database Syst Rev ; 2:CD001903
16. Morandi, G., Guido, D., & Tagliabue, A. (2015). A bibliometric study of scientific literature on the dietary therapies for epilepsy in Scopus. Nutr Neurosci;18:201–9.
17. Marshalick, BE., & Fenko, AN. (1991). The use of radon baths for rehabilitating the immune system of patients with bronchial asthma. VoprKurortol Fiziother LechFiz Kult. 1991;6:6–10.
18. Nikolashvili, M., Mchedluri, T., Museliani, T. (2006). Effect of tskaltubo radon mineral waters on aggressive behaviour of animals and distribution of free amino acids in structures if the brain. saq. mecn. Acad. Mmacne, ser. Bboil. A t 32, N1. 119-123.
19. Nikolashvili, M., Nanobashvili, Z., & Mitagvaria, N. (2021). Radon hormesis in epileptic phatogenesis ans predictors of oxidative stress Georgian Medical News, No 4 (313).
20. Pandey, M.K., Mittra, P., & Maheshwari, P.K. (2012). The Lipid Peroxidation Product as a Marker of Oxidative Stress in Epilepsy.
21. Raimondo, J.V., Burman, R.J., Katz, A.A., Akerman, C.J. (2015). Ion dynamics during seizures. Front. Cell. Neurosci., 9, 419.
22. Ryan, MJ., Jackson, JR., Hao, Y., & Leonard, SS., Always, SE. (2011). Inhibition of xanthine oxidase reduces oxidative stress and improves skeletal muscle function in response to electrically stimulated isometric contractions in aged mice. Free Radic Biol Med.; 51(1):38-52. doi:10.1016/j.freeradbiomed.2011.04.002
23. Ross, K.C., & Coleman, J.R. (2000). Developmental and genetic audiogenic seizure models: behavior and biological substrates. Neuroscience and Biobehavioral Reviews, 2000, 24, 639-653
24. Shultz, S.R., O’Brien, T.J., Stefanidou, M., & Kuzniecky, R.I. (2014). Neuroimaging the epileptogenic process. Neurother. J. Am. Soc. Exp. Neurother. 11, 347–357
25. Silva, L.F., Hoffmann, M.S., Rambo, L.M., Ribeiro, L.R., Lima, F.D., Furian, A.F., Oliveira, M.S., Fighera, M.R., & Royes, L.F. (2011). The involvement of Na+/K+-ATPase activity and free radical generation in the susceptibility to pentylenetetrazol-induced seizures after experimental traumatic brain injury. J. Neurol. Sci. , 308, 35–40.
26. Sedlak, J., & Landsay, R. (1968). Biochem. 25, 192-205.
27. Yarmoshenko, IV. (2002). Meta-analysis of 18 radon and lung cancer case control studies. In: Proceedings of the 7th International Symposium, Natural Radiation Environment (NRE VII), Rhodes, May, Elsevier Conf. Series, in press
28. Yuta Shibamoto & Hironobu Nakamura (2018). Overview of Biological, Epidemiological, and Clinical Evidence of Radiation Hormesis. Int J Mol Sci.; 19, (8):2387
29. Zharkinbekova, N.A., & Ormanov, N.Z. (2019). Lipid Peroxidation and the Antioxidant System in the Blood of Epileptic Patients. Neurochem. J. 13, 378–384.
Published
2022-04-30
How to Cite
Marine, N., Zakharia, N., Nodar, M., Gvantsa, C., Irina, B., Ekaterine, N., T, R., Tea, M., Khatuna, D., & Gogi, J. (2022). Hormesis Effect of Radon in Rats of the Krushinsky-Molodkina Line. European Scientific Journal, ESJ, 18(14), 1. https://doi.org/10.19044/esj.2022.v18n14p1
Section
ESJ Natural/Life/Medical Sciences
Copyright (c) 2022 Nikolaishvili Marine, Nanobashvili Zakharia, Mitagvaria Nodar, Chkadua Gvantsa, Bilanishvili Irina, Nozadze Ekaterine, Rtveladze T, Museliani Tea, Dondoladze Khatuna, Jikia Gogi
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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