Hormesis Effect of Radon in Rats of the Krushinsky-Molodkina Line

  • Nikolaishvili Marine Doctor of Biological Sciences, Head of the Laboratory of Radiobiology, Ivane Beritashvili Center of Experimental Biomedicine, Georgia
  • Nanobashvili Zakharia Doctor of Biological Sciences, Head of the Laboratory of Neurophysiology, Ivane Beritashvili Center of Experimental Biomedicine, Georgia
  • Mitagvaria Nodar Academician/Professor, Secretary at Department of Physiology and Medicine, Georgian National University Academy of Sciences, Head of the Laboratory of Cerebral Circulation and Metabolism, Beritashvili Center of Experimental Biomedicine, Georgia
  • Chkadua Gvantsa Doctor of Biological Sciences, Director of Ivane Beritashvili Center of Experimental Biomedicine, Georgia Associate Professor at Georgian National University, Faculty of Medicine, Georgia
  • Bilanishvili Irina Doctor of Biology, Main Scientist at Ivane Beritashvili Center of Experimental Biomedicine Laboratory of Neurophysiology, Georgia
  • Nozadze Ekaterine Doctor of Biology, Head of the Laboratory of Membranology, Ivane Beritashvili Center of Experimental Biomedicine, Georgia
  • Rtveladze T PhD Student, Laboratory of Cerebral Circulation and Metabolism, Ivane Beritashvili Center of Experimental Biomedicine, Georgia
  • Museliani Tea Doctor of Biology, Chief Researcher at the Department of Radiobiology Laboratory, Ivane Beritashvili Center of Experimental Biomedicine Assistant Professor at European University, Georgia
  • Dondoladze Khatuna PhD Student/Researcher, Laboratory of Radiobiology, Ivane Beritashvili Center of Experimental Biomedicine Invited Lecturer at European University, Georgia
  • Jikia Gogi Doctor of Biology, Senior Researcher at Laboratory of Radiobiology, Ivane Beritashvili Center of Experimental Biomedicine Assistant Professor at David Agmashenebeli University of Georgia, Faculty of Medicine and Dentistry, Georgia
Keywords: Radon, Epileptic rats, Oxidative stress, Sulfhydryl groups


According to this research, the use of radon inhalation in experimental animals, particularly in genetically determined rats with epileptic seizures, altered all parameters of the epileptic seizure development picture, namely the hidden period and the first and second wild jog duration after the audiogenic signal. On the third day, no response to the audiogenic signal was observed at all, and there was not even a single episode of tonic-clonic seizures. All what was mentioned suggests that radon inhalation can be used to treat epilepsy. This study is the first precedent of attempting R-Ho through inhalation for treatment of epileptic seizures in animal models with further translation to clinical study in humans through pilot phase II study. More profound and scientifically systematized approach is needed to determine the uniqueness of Tskhaltubo water springs, investigating the mechanisms of radon effects on the excitatory and inhibitory functioning of CNS, and the use of further clinical studies to establish its effectiveness on humans.



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How to Cite
Marine, N., Zakharia, N., Nodar, M., Gvantsa, C., Irina, B., Ekaterine, N., T, R., Tea, M., Khatuna, D., & Gogi, J. (2022). Hormesis Effect of Radon in Rats of the Krushinsky-Molodkina Line. European Scientific Journal, ESJ, 18(14), 1. https://doi.org/10.19044/esj.2022.v18n14p1
ESJ Natural/Life/Medical Sciences