Current Perspectives in the Use of Phytotherapy for the Treatment of Breast Cancer
Keywords:
Breast cancer, phytotherapy, anti-breast cancer properties, plant extracts
Abstract
Breast cancer is the most commonly diagnosed cancer leading to death among women worldwide. However, there is a significant improvement in the treatment of breast cancer. Today, the conventional treatment of breast cancer combines surgery , chemotherapy, radiation, targeted therapy, hormone therapy and immunotherapy. Despite the advances in the diagnosis skills and in the treatment of breast cancer it has been observed that the recurrence rate experienced by breast cancer patients is quite high. Moreover, the conventional treatment is often accompained with side effects. Thus, there is a need to search for new bioactive molecules. Plant derived natural compounds can play a major role as sources of new bioactive substances for the treatment of breast cancer. Many plants have been reported to have anti-breast cancer properties. While investigations are being made to demonstrate the cytotoxic activities of many plants, the use of phytomedicine is not generating fully attention by mainstream practitioners. Some significant results were observed by patients with breast cancer history by combining phytotherapy and the conventional medicines. Hence, plant extracts are more being used in the treatment of breast cancer as adjuvant therapy. In this review we will present a summary of the advances of the researches on the efficacity of phytotherapeutic products when discussing their use in the treatment of breast cancer.
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References
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29. Samuelsson, G. (2004). Drugs of Natural Origin: A Textbook of Pharmacognosy, 5th Edn. Stockholm: Swedish Pharmaceutical Press;
30. Sharaf, M., El-Ansari, M. A., & Saleh, N. A. (2000). New flavonoids from Avicennia marina. Fitoterapia, 71(3):274-277. Doi: 10.1016/s0367-326x(99)00169-0. PMDI:10844167
31. Stuffness, M., & Douros, J. (1982). Current status of the NCI plant and animal product program J. Nat. Prod.; 45 (1): 1-14. Doi: 10.1021np500019a001.PMDI:7069421
32. Thirumal, M., Kishore, G., Prithika, R., Das, S., & Nithya, G. (2012). In-vitro anticancer activity of tecomastans (L) Ethanolic leaf extract on human breast cancer cell line (mcf-7) int. j of pharm., chem. and biol. Sciences, 2 (4): 488-493
2. Al-Asmari A. K., Albalawi, S. M., Athar, M. T, Khan, A. Q., Al-Shahrani, H., & Islam, M. (2015). Moringa oleifera as an anti-cancer agent against breast and colorectal cancer cell lines. PloS ONE, 10 (8): e0135814.
3. Baker, J. T., Borris, R. P., Carté, B., Cordell, G. A., Soejarto, D. D., Cragg G. M., Gupta, M. P., Iwu, M. M., Madulid, D. R., & Tyler, V. E. (1995). Natural product drug discovery and development: New perspective on international collaboration. J. Nat. Prod., 58 (9): 1325-1357
4. Baltina, L. A.(2003). Chemical modification of glycyrrhizic acid as a route to new bioactive compounds for medicine. Curr Med Chem., 10 (2):155-171.doi: 10.2174/09298670333368538. PMID:12570715
5. Chan, T.Y., Chan, J.C., Tomlinson, B., & Critchley, J. A. (1993). Chinese herbal medicines revisited: a Hong Kong perspective. Lancet., 342(8886-8887):1532-1534.
6. Chin, Y-W., Balunas, M. J., Chai, H. B., & Kinghorn, A. D. (2006). Drug discovery from natural sources. AAPSJ., 8(2) E239-E253.
7. Cordell, G.A. (1995). Changing strategies in natural products chemistry. Phytohemistry, 40 (6): 1585-1612
8. Cortella, A. R., & Pocheltino, M. L. (1999). Plants employed for hypotensive infusions in urban areas of Argentina. Pharm. Biol., 37 (2): 97-104.
9. Dobos, G. J., Voiss, P., Schwidde, I., Choi, K. E., Paul, A., Kirschbaum, B., Saha, F. J., & Kuemmel, S. (2012). Integrative oncology for breast cancer patients: Introduction of an expert-based model. BMC Cancer, 12: 539 doi: 10.1186/1471-2407-12-539. PMDI:23170989; PMCID:PMC3582454
10. Endrini, S., Suherman, S., & Widowati, W. (2014). Annona muricata leaves have strongest cytotoxic activity against breast cancer cells. Universa Medicina, 33(3): 179–184. https://doi.org/10.18051/UnivMed.2014.v33.179-184
11. Fallah, H. H., Zahmatkash, M., & Haghighi, M. (2010). A review on pharmacological effects of Curcuma longa L. (turmeric). JMP., 9 (33):1-15.
12. Fridlender, M., Kapulnik, Y., & Koltai, H. (2015). Plant derived substances with anti-cancer activity: from folklore to practice. Front. Plant Sci., (6):799. doi: 10.3389/fpls.2015.00799
13. Fulda, S. (2010). Evasion of apoptosis as a cellular stress response in cancer. Int. J. Cell Biol., 2010:37085. Doi.10.155/2010/37085.Epub 2010 Feb18. PMID:2018259; PMCID: PMC282555
14. Kinghorn, A. D. (2001). Pharmacognosy in the 21st century. J. Pharm. Pharmacol., 53(2): 135-148. doi:10.1211/0022357011775334.PMID:1273009
15. Ma, H., Carpenter, C. L., Sullivan-Halley, J., & Bernstein, L. (2011). The roles of herbal remedies in survival and quality of life among long-term breast cancer survivors - results of a prospective study. BMC Cancer, 11 (1): 1-10.
16. Mbikay, M. (2012). Therapeutic potential of Moringa oleifera leaves in chronic hyperglycemia and dyslipidemia: A review. Front Pharmacol., (3):24. doi: 10.3389/fphar.2012.00024.PMDI: 22403543; PMCID: PMC 3290775
17. Nagykalnai, T., Landherr, L., & Nagy, A. C. (2014). Vitamin D and breast cancer. Orvosi Hetilap., 155 (28):1091–1096.
18. Nawal, H., & Atta, E. M. (2013). Cytotoxic and Antioxidant Activity of Marrubium vulgare and its Flavonoid Constituents. In: 2nd Environmental Conference on Chemical and Biological Sciences, 17-18; Dubai, (UAE).
19. Newman, D. J., Cragg, G. M., & Snader, K. M. (2003). Natural products as sources of new drugs over the period 1981–2002. J. Nat. Prod., 66 (7):1022-1037. doi: 10.1021/np030096l. PMDI: 12880330
20. Nishimura, H., Ariga, T., Huang, M., Osawa, T., Ho, C., & Rosen, R. (1993).
Phytochemicals food for Cancer Prevention. IACS Symposium Series, pp.128-143
21. Nunuk, H., Yuniata, Y., Harijono, H., & Wijarnako, S. B. (2020). Cytotoxic activity and selectivity index of Solanum Torvum Fruit on T47D breast cancer cells. Ind J Public Health Research and Dev., 11 (2): 1397-1402. doi: 10.37506/v11/12/2020/ijphrd/195053
22. Olson, M. E. (2002). Combining data from DNA sequences and morphology for aphylogeny of Moringaceae (Brassicales). Systematic Botany, 27 (1): 55–73.
23. Omogbadegun, Z. O.(2013). Medicinal plants-based foods for breast cancer treatment: an ethnobotanical survey and digitization. Int J Med Plants and Alternative Medicine, 1, (8)137-163
24. Parkin, D. M., Bray F.I., & Devesa S. S. (2001). Cancer burden in the year 2000. The global picture. European Journal of Cancer; Suppl 8: S4-66. Doi: 10.1016/s0959-8049(01)00267-2. PMDI:11602373
25. Ranjbari, J., Alibakhshi, A., Arezumand, R., Pourhassan-Moghaddam, M., Rahmati, M., Zarghami, N., & Namvaran M. M. (2014). Effects of Curcuma longa extract on telomerase activity in lung and breast cancer cells. Zahedan J Res Med Sci.,16 (10):1-6.
26. Rossi, R. E., Pericleous, M., Mandair, D., Whyand, T., & Caplin, M. E. (2015). The role of dietary factors in prevention and progression of breast cancer. Anticancer Research, 34 (12): 6861–6875
27. Rossi, T., Castelli, M., Zandomeneghi, G., Ruberto, A., Benassi, L., & Magnoni, C. (2003). Selectivity of action of glycyrrhizin derivatives on the growth of MCF-7 and HEP-2 cells. Anticancer Res., 23 (5A):3813-3818.
28. Sakarkar, D. M., & Deshmukh, V. N. (2011). Ethnopharmacological Review of Traditional Medicinal Plants for Anticancer Activity. International Journal of Pharm Tech Research, 3 (1): 298-308.
29. Samuelsson, G. (2004). Drugs of Natural Origin: A Textbook of Pharmacognosy, 5th Edn. Stockholm: Swedish Pharmaceutical Press;
30. Sharaf, M., El-Ansari, M. A., & Saleh, N. A. (2000). New flavonoids from Avicennia marina. Fitoterapia, 71(3):274-277. Doi: 10.1016/s0367-326x(99)00169-0. PMDI:10844167
31. Stuffness, M., & Douros, J. (1982). Current status of the NCI plant and animal product program J. Nat. Prod.; 45 (1): 1-14. Doi: 10.1021np500019a001.PMDI:7069421
32. Thirumal, M., Kishore, G., Prithika, R., Das, S., & Nithya, G. (2012). In-vitro anticancer activity of tecomastans (L) Ethanolic leaf extract on human breast cancer cell line (mcf-7) int. j of pharm., chem. and biol. Sciences, 2 (4): 488-493
Published
2023-03-10
How to Cite
Anago, A. D., Segbo, J. A. G., Gnangnon, F., Akpovi, C. D., & Agbangla, C. (2023). Current Perspectives in the Use of Phytotherapy for the Treatment of Breast Cancer. European Scientific Journal, ESJ, 15, 156. Retrieved from https://eujournal.org/index.php/esj/article/view/16519
Section
ESI Preprints
Copyright (c) 2023 Afiwa Dodzi Anago, Julien A. Gaetan Segbo, Freddy Gnangnon, Casimir D. Akpovi, Clement Agbangla
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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