Hypoglycemic Activity of Hydro-Acetonic and HydroMethanolic Leaf and Bark Extracts of Bauhinia rufescens Lam in Mice
Keywords:
Bauhinia rufescens Lam, hypoglycemia activities, glibenclamide
Abstract
The purpose of this study was to determine the hypoglycaemic effects of leaf and bark extracts of Bauhinia rufescens Lam, used in traditional medicine for diabetes in Senegal. Phytochemical screening of hydromethanolic and hydro-acetonic extracts obtained from leaves and barks was carried out according to standard analytical methods. Experiments were carried out on normoglycemic and diabetic mice. These were obtained after the injection of a single dose of glucose (4 g/kg of body weight). The results showed that polyphenolic compounds, tannins, and flavonoids were the main phytochemical constituents of the extracts. Then the oral administration of the different extracts of Bauhinia rufescens Lam at doses of 500, 700, and 1000 mg/kg of body weight led to a significant reduction in blood sugar (p < 0.05), similar to the antidiabetic action of glibenclamide (10 mg/kg of body weight). Whatever the organ and the extraction solvent, the doses of 500 and 700 mg/kg of body weight induced dose-dependent hypoglycemia, just like glibenclamide. These results show that the metabolites revealed in the extracts could be responsible for their hypoglycemic effects. Thus, supported by a complete chemical study with a view to isolating the active substances responsible for the antidiabetic effect is possible. It will be allowed to formulate from a phytomedicine with potential for diabetes which makes possible their uses by populations for treatment of diabetes.
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References
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20. Nissen S. E., & Wolski K. (2007). Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. New England Journal of Medicine, 356 (24): 2457-2471.
21. Olapade E. O. (1995). Food and herbs for diabetes mellitus and hypertension. National Cures Series , 1: 3-6.
22. Pallavi, S.M.A., H., & Baheti, A.M. (2020). Pharmacognostic and Phytochemical Investigations of Bahunia Variegata Leaves (Kovidra). 4, Article ID: 000205.
23. Rasyid, Z. A., Farida, A., Daud, S. H., Wiwin, S., Wijaya, K. I. H., & Tangke, A. E. (2020). Bioactivities of Forest Medicinal Plants on Kutai Ethnic (Indonesia) of Tapak Leman (Hippobroma Longiflora (L) G. Don). GSC Biological and Pharmaceutical Sciences. 11: 91-98.
24. Sakine, M. N. A., Mahmout, Y., Gbenou, J., Agbodjogbe, W. H., & Moudachirou, M. (2011). Inventaire ethnobotanique des plantes du Tchad utilisées contre le diabète: Effet anti- hyperglycémiant des extraits de Boscia senegalensis (Pers.) Lam. ex Poiret et de Colocynthisvulgaris (Schrad.). Phytothérapie, 9: 268-273.
25. Sharma V. K., Kumar S., Patel H. J. H., & Hugar S. (2001). Hypoglycaemic Activity of Ficus glomerata in alloxan induced diabetic rats. International Journal of Pharmaceutical Sciences, Reviewand Research. 1(2): 18-21.
26. Sen, S., H., & Chakraborty, R. (2011). The Role of Antioxidants in Human Health. ACS Symposium Series, 1083: 1-37.
27. Sofowora, A. (1993). Medicinal Plants and Traditional Medicine in Africa. 2nd Edition,Spectrum Books Limited, Ibadan, 14-34.
28. Usman, H., Abdulrahman, F. I., Abdu-Kaita, I. H., & Khan, I.Z. (2009). Phytochemical and In- Vitro Antibacterial Effects of the Partitioned Portions of Bauhinia rufescens Lam Stem Bark Extract. African Journal of Biomedical Research. 12: 210-218.
29. Wild S. G., Roglic A., Green R. H., & King H. (2004). Global prevalence of diabetes estimated for the year 2000 and projection for 2030. Diabetes Care 27:1047-1054.
30. World Health Organization (2013). WHO Traditional Medicine Strategy: 2014-2023. World Health Organization, Geneva, 1- 4.
31. Yasodha K. J., Jayaveera K. N., Ravindra R. K., Rupesh K. H., & Raghavendra D. (2008). Anti- diabetic activity of aqueous extract of Tali-num cuncifolium in rats. Pharmacologyline, 2: 198 - 206
2. Antiochia, R., Gatta, T., Mazzone, E., Mannina, L., H. & Campanella, L. (2011). A Comparison among Three Different Analytical Methods to Test the Scavenging Properties of Different Integrators against Radicalic Stress. Pakistan Journal of Pharmaceutical Sciences, 27: 25-32.
3. Chaibou, M., Hamadou, H. H., & Moussa, A.N. (2020). In Vitro Study of the Anthelmintic Effects of Ethanolic Extracts of Bauhinia rufrescens Lam. (Fabaceae) and Chrozophora brocchiana (Vis) Schweinf (Euphorbiaceae) Two Plants Used as Antiparasitic in Azawagh Area in Niger. Journal of Pharmacognosy and Phytochemistry. 9: 944-948.
4. Codonier-Franch, P., Boix-Garcia, L., Simo-Jorda, R., Castillo-Villaescusa, C. D., Maset- Maldonado, J. H., & Valls-Belles, V. (2010). Is Obesity Associated with Oxidative Stress in Children. International Journal of Pediatric Obesity. 5: 56-63.
5. Essien, G.E., Sunday, T. P. H., & Udoette, I. M. (2020). In Vitro Antioxidant Analysis and Quantitative Determination of Phenolic and Flavonoid Contents of Emilia sonchifolia (L) D.C (Asteraceae) Leaf Extract and Fractions . GSC Biological and Pharmaceutical Sciences. 11: 44-52.
6. Folié, N. B. Y., Kouakou, L.P.M.S., Coulibaly, K., Sanogo, R. H., & Koné-Bamba, D. (2017). Composition en sels minéraux et en métabolites secondaires de Ziziphus mauritiana Lam., une plante antihyperglycémiante. Journal de la Société Ouest-Africaine de Chimie, 44: 30-35.
7. Halliwell, B. (2018). Free Radicals and Antioxidants in Food and in Vivo: What They Do and How They Work Section II: The Role of Free Radicals and Antioxidants. Critical Reviews in Food Science and Nutrition, 35, 7-20.
8. Jackson J. E. H. & Bressler R. (1981). Clinical pharmacology of sulphonylurea hypoglycemic agents. Part I. DRUG, 212, 211 - 245.
9. Karumi, Y., Onyeyili, P.A. H., & Ogugbuaja, V.O. (2004). Identification of Active Principles of M. Balsamina (Balsam Apple) Leaf Extract. Journal of Medical Sciences. 4: 179-182.
10. Khajapeer, K.V., Biswal, R. H., & Baskaran, R. (2018). Evaluation of Anti-CML Activity of Methanol and Aqueous Extracts of Benkara malabarica (Lam.) Tirveng Plant Leaves. International Journal of Pharmacy and Pharmaceutical Sciences. 10: 1-7.
11. Kim S. H., Hyun S. H., & Choung S. Y. (2006). Anti-diabetic effect of cinnamon extract on blood glucose in db/db mice. Journal of ethnopharmacology, 104 (2): 119-123.
12. Lu, Y., Hernandez, P. H., & Edejer, T. (2011). The World Medicines Situation 2011 Medicine Expenditures.
13. Mahamat, S. A., Niang L, Ayessou N. C, Cisse M. H., & Diop C. M. (2021). Phytochemical Screening, Total Phenolic and Antioxidant Activity of Numerous Extracts from Leaves and Bark of Bauhinia rufescens Lam. Food and Nutrition Sciences. 12: 544 - 556.
14. Mamadou, R.S., Moussa, I., Sessou, P., Yehouenou, B., Agbangnan, P.D.C., Illagouma, A.T., Abdoulaye, A., Sohounhloué, D.C.K. H., & Ikhiri, K. (2014). Etude phytochimique, activités antiradicalaire, antibactérienne et antifongique d’extraits de Sebastiania chamaelea (L.) Müll. Journal de la Société Ouest-Africaine de Chimie. 37: 10-17.
15. Miliauskas, G., Venskutonis, P. R. H., & Van-Beek, T. A. (2004). Screening of Radical Scavenging Activity of Some Medicinal and Aromatic Plant Extracts. Food Chemistry, 85: 231-237.
16. N’doua, L. A. R., Abo K. J. C., Aousi S., Gbogbo M., Yapo A. P., H. & Ehile E. E. (2015). Effets hypoglycemique et antihyperglycemique de l’extrait ethanolique 70 % de racines de Rauvolfia vomitoria afzel (apocynaceae). European Scientific Journal. 151(2): 10-17.
17. Ngarnougber, C., Ngaryo, F. T. H., & Adamou, I. (2017). Caractérisation des ligneux de la savane sahélienne à Acacia Sénégal (L) Willd dans la région du Guéra, Tchad. International Journal of Applied Research. 3: 600-606.
18. NIANG, L. (2022) Caractérisation phytochimique, activité antioxydante et antidiabétique de deux plantes médicinales: Sclerocarya birrea (a.rich.) Hochst et Bauhinia rufescens Lam Thèse de doctorat, Génie des Procédés et Environnement, Université Cheikh Anta Diop de Dakar, Sénégal.
19. Niang, L., Mahamat, S. A., Ayessou, N. C., Cisse, M. H., & Diop, C. M. (2021). Antioxidant Activity of Hydro-Acetonic, Hydro-Methanolic and Aqueous Leaf and Bark Extracts of Sclerocaria birrea L. (A. Rich.) Hochst. Food and Nutrition Sciences. 12: 429-438.
20. Nissen S. E., & Wolski K. (2007). Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. New England Journal of Medicine, 356 (24): 2457-2471.
21. Olapade E. O. (1995). Food and herbs for diabetes mellitus and hypertension. National Cures Series , 1: 3-6.
22. Pallavi, S.M.A., H., & Baheti, A.M. (2020). Pharmacognostic and Phytochemical Investigations of Bahunia Variegata Leaves (Kovidra). 4, Article ID: 000205.
23. Rasyid, Z. A., Farida, A., Daud, S. H., Wiwin, S., Wijaya, K. I. H., & Tangke, A. E. (2020). Bioactivities of Forest Medicinal Plants on Kutai Ethnic (Indonesia) of Tapak Leman (Hippobroma Longiflora (L) G. Don). GSC Biological and Pharmaceutical Sciences. 11: 91-98.
24. Sakine, M. N. A., Mahmout, Y., Gbenou, J., Agbodjogbe, W. H., & Moudachirou, M. (2011). Inventaire ethnobotanique des plantes du Tchad utilisées contre le diabète: Effet anti- hyperglycémiant des extraits de Boscia senegalensis (Pers.) Lam. ex Poiret et de Colocynthisvulgaris (Schrad.). Phytothérapie, 9: 268-273.
25. Sharma V. K., Kumar S., Patel H. J. H., & Hugar S. (2001). Hypoglycaemic Activity of Ficus glomerata in alloxan induced diabetic rats. International Journal of Pharmaceutical Sciences, Reviewand Research. 1(2): 18-21.
26. Sen, S., H., & Chakraborty, R. (2011). The Role of Antioxidants in Human Health. ACS Symposium Series, 1083: 1-37.
27. Sofowora, A. (1993). Medicinal Plants and Traditional Medicine in Africa. 2nd Edition,Spectrum Books Limited, Ibadan, 14-34.
28. Usman, H., Abdulrahman, F. I., Abdu-Kaita, I. H., & Khan, I.Z. (2009). Phytochemical and In- Vitro Antibacterial Effects of the Partitioned Portions of Bauhinia rufescens Lam Stem Bark Extract. African Journal of Biomedical Research. 12: 210-218.
29. Wild S. G., Roglic A., Green R. H., & King H. (2004). Global prevalence of diabetes estimated for the year 2000 and projection for 2030. Diabetes Care 27:1047-1054.
30. World Health Organization (2013). WHO Traditional Medicine Strategy: 2014-2023. World Health Organization, Geneva, 1- 4.
31. Yasodha K. J., Jayaveera K. N., Ravindra R. K., Rupesh K. H., & Raghavendra D. (2008). Anti- diabetic activity of aqueous extract of Tali-num cuncifolium in rats. Pharmacologyline, 2: 198 - 206
Published
2023-05-31
How to Cite
Niang, L., Seid Ali, M., Faye, P. G., Ayessou, N. C., & Cisse, M. (2023). Hypoglycemic Activity of Hydro-Acetonic and HydroMethanolic Leaf and Bark Extracts of Bauhinia rufescens Lam in Mice. European Scientific Journal, ESJ, 19(15), 198. https://doi.org/10.19044/esj.2023.v19n15p198
Section
ESJ Natural/Life/Medical Sciences
Copyright (c) 2023 Lahat Niang, Mahamat Seid Ali, Papa Guédel Faye, Nicolas Cyrille Ayessou, Mady Cisse
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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