Intra-abdominal metastasis after pelvic primary Synovial Sarcoma resection: case report
Keywords:
Synovial sarcoma; soft tissue sarcoma, metastatic sarcoma
Abstract
Introduction: Synovial sarcoma is a malignant soft tissue sarcoma. It occurs predominantly in young adults. 90% of synovial sarcomas occur in the extremities, they have been reported in other sites, including abdomen and pelvis. Up to 40% of all patients with soft tissue sarcomas develop distant metastasis, despite adequate local disease control.
Aim of the article: To provide an update on one of the rarest and most aggressive tumors, to affirm the importance of early management and especially surveillance, and to encourage the codification and the management of these tumors.
Presentation of cases: Here, we discuss a case of a 78-year-old female patient, operated 10 years earlier for a pelvic Synovial sarcoma, who presented with intra-abdominal mass to our hospital that eventually turned out to be a metastatic intra-abdominal synovial sarcoma following biopsy.
Conclusion: It is important to be aware that primary intraabdominal tumors can occur and delayed metastasis is more typical of synovial sarcoma than of many other sarcomas and should be considered in determining the appropriate frequency and duration of follow-up imaging.
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References
1. Thway K, Fisher C. Synovial sarcoma: defining features and diagnostic evolution. Ann Diagn Pathol. 2014;18:369–80.
2. Fisher C. Synovial sarcoma. Ann Diagn Pathol. 1998;2:401–21.
3. Bakri A, Shinagare AB, Krajewski KM, et al. Synovial sarcoma: imaging features of common and uncommon primary sites, metastatic patterns, and treatment response. AJR Am J Roentgenol 2012;199(2):W208-215. PMID: 22826423.
4. Ferrari A, Gronchi A, Casanova M, et al. Synovial sarcoma: a retrospective analysis of 271 patients of all ages treated at a single institution. Cancer 2004;101(3):627-634. PMID: 15274077.
5. Pisters PW, Leung DH, Woodruff J, Shi W, Brennan MF. Analysis of prognostic factors in 1041 patients with localized soft tissue sarcomas of the extremities. J Clin Oncol 1996;14:1679–89.
6. Braham E, Aloui S, Aouadi S, Drira I, Kilani T, El Mezni F (2013) Synovial sarcoma of the chest wall: a case report and literature review. Ann Transl Med 1(1)
7. Weiss SW, Goldblum JR (2001) Enzinger and Weiss’s soft tissue tumors. Mosby. Inc. A Harcourt Health Sciences Company, St Louis
8. Murphey MD, Gibson MS, Jennings BT, Crespo-Rodríguez AM, Fanburg-Smith J, Gajewski DA (2006) Imaging of synovial sarcoma with radiologic-pathologic correlation. Radiographics 26(5): 1543–1565
9. Brennan MF, Singer S, Maki RG, et al. Sarcomas of the soft tissues and bone. In: DeVita VT, Hellmann S, Rosenberg SA, eds. Cancer: principles and practice of oncology, vol. 35. Philadelphia, PA: Lippincott Williams & Wilkins, 2005:1584
10. Kransdorf MJ. Malignant soft-tissue tumors in a large referral population: distribution of diagnoses by age, sex, and location. AJR 1995; 164:129–134
11. O’Sullivan PJ, Harris AC, Munk PL. Radiological features of synovial cell sarcoma. Br J Radiol2008; 81:346–356
12. Jones BC, Sundaram M, Kransdorf MJ. Synovial sarcoma: MR imaging findings in 34 patients. AJR 1993; 161:827–830 13. Krieg AH, Hefti F, Speth BM, et al. Synovial sarcomas usually metastasize after > 5 years: a multicenter retrospective analysis with minimum follow-up of 10 years for survivors. Ann Oncol 2011; 22:458–467
13. Perlmutter AE, Saunders SE, Zaslau S, Chang WW, Farivar-Mohseni H. Primary synovial sarcoma of the kidney. Int J Urol 2005; 12:760–762
14. Jaques DP, Coit DG, Casper ES, Brennan MF. Hepatic metastases from soft-tissue sarcoma. Ann Surg 1995; 221:392–397
15. Singer S, Baldini EH, Demetri GD, Fletcher JA, Corson JM. Synovial sarcoma: prognostic significance of tumor size, margin of resection, and mitotic activity for survival. J Clin Oncol 1996; 14:1201–1208
16. Eilber FC, Dry SM. Diagnosis and management of synovial sarcoma. J Surg Oncol 2008; 97:314–320
17. Skinner KA, Eilber FR: Soft tissue sarcoma nodal metastases: Biologic significance and therapeutic considerations. Surg Oncol Clin N Am 1996;5:121–127.
18. Trassard M, Le Doussal V, Hacene K, et al.: Prognostic factors in localized primary synovial sarcoma: A multicenter study of 128 adult patients. J Clin Oncol 2001;19:525–534.
19. Guillou L, Benhattar J, Bonichon F, et al.: Histologic grade, but not SYT-SSX fusion type, is an important prognostic factor in patients with synovial sarcoma: A multicenter, retrospective analysis. J Clin Oncol 2004;22:4040–4050.
20. Hasegawa T, Yamamoto S, Yokoyama R, et al.: Prognostic significance of grading and staging systems using MIB-1 score in adult patients with soft tissue sarcoma of the extremities and trunk. Cancer 2002;95:843–851.
21. Guillou L, Coindre JM, Bonichon F, et al.: Comparative study of the National Cancer Institute and French Federation of Cancer Centers Sarcoma Group grading systems in a population of 410 adult patients with soft tissue sarcoma. J Clin Oncol 1997;15: 350–362.
22. Hasegawa T, Yokoyama R, Matsuno Y, et al.: Prognostic significance of histologic grade and nuclear expression of betacatenin in synovial sarcoma. Hum Pathol 2001;32:257–263.
23. Weiss SW, Goldblum J, Malignant soft tissue tumors of uncertain type. In: Weiss SW, Goldblum JR, editors. Enzinger and Weiss’s soft tissue tumors. CV Mosby: St. Louis; 2001. pp 1483–1571.
24. Fletcher CD, Unni KK, Mertens F, editors. Pathology and genetics of tumours of the soft tissues and bones. World Health Organization Classification of Tumours. Lyon: W.H. Organization; 2003.
25. Rosen G, Forscher C, Lowenbraun S, et al.: Synovial sarcoma: Uniform response of metastases to high dose ifosfamide. Cancer 1994;73:2506–2511.
26. Kampe CE, Rosen G, Eilber F, et al.: Synovial sarcoma: A study of intensive chemotherapy in 14 patients with localized disease. Cancer 1993;72:2161–2169.
27. Landenstein R, Treuner J, Koscielniak E, et al.: Synovial sarcoma of childhood and adolescence: Report of the German CWS-81 study. Cancer 1993;71:3647–3655.
28. Okcu MF, Munsell M, Treuner J, et al.: Synovial sarcoma of childhood and adolescence: A multicenter, multivariate analysis of outcome. J Clin Oncol 2003;21:1602–1611.
29. Spurrell EL, Fisher C, Thomas M, et al.: Prognostic factors in advanced synovial sarcoma: An analysis of 104 patients treated at the Royal Marsden Hospital. Ann Oncol 2005;16:437–444.
30. Brodowicz T, Schwameis E, Widder J, et al.: Intensified adjuvant IFADIC chemotherapy for adult soft tissue sarcoma: A prospective randomized feasibility trial. Sarcoma 2000;4:151–160.
31. Gortzak E, Azzarelli A, Buesa J, et al.: A randomized phase II study on neo-adjuvant chemotherapy for ‘‘high-risk’’ adult softtissue sarcoma. Eur J Cancer 2001;37:1096–1103.
2. Fisher C. Synovial sarcoma. Ann Diagn Pathol. 1998;2:401–21.
3. Bakri A, Shinagare AB, Krajewski KM, et al. Synovial sarcoma: imaging features of common and uncommon primary sites, metastatic patterns, and treatment response. AJR Am J Roentgenol 2012;199(2):W208-215. PMID: 22826423.
4. Ferrari A, Gronchi A, Casanova M, et al. Synovial sarcoma: a retrospective analysis of 271 patients of all ages treated at a single institution. Cancer 2004;101(3):627-634. PMID: 15274077.
5. Pisters PW, Leung DH, Woodruff J, Shi W, Brennan MF. Analysis of prognostic factors in 1041 patients with localized soft tissue sarcomas of the extremities. J Clin Oncol 1996;14:1679–89.
6. Braham E, Aloui S, Aouadi S, Drira I, Kilani T, El Mezni F (2013) Synovial sarcoma of the chest wall: a case report and literature review. Ann Transl Med 1(1)
7. Weiss SW, Goldblum JR (2001) Enzinger and Weiss’s soft tissue tumors. Mosby. Inc. A Harcourt Health Sciences Company, St Louis
8. Murphey MD, Gibson MS, Jennings BT, Crespo-Rodríguez AM, Fanburg-Smith J, Gajewski DA (2006) Imaging of synovial sarcoma with radiologic-pathologic correlation. Radiographics 26(5): 1543–1565
9. Brennan MF, Singer S, Maki RG, et al. Sarcomas of the soft tissues and bone. In: DeVita VT, Hellmann S, Rosenberg SA, eds. Cancer: principles and practice of oncology, vol. 35. Philadelphia, PA: Lippincott Williams & Wilkins, 2005:1584
10. Kransdorf MJ. Malignant soft-tissue tumors in a large referral population: distribution of diagnoses by age, sex, and location. AJR 1995; 164:129–134
11. O’Sullivan PJ, Harris AC, Munk PL. Radiological features of synovial cell sarcoma. Br J Radiol2008; 81:346–356
12. Jones BC, Sundaram M, Kransdorf MJ. Synovial sarcoma: MR imaging findings in 34 patients. AJR 1993; 161:827–830 13. Krieg AH, Hefti F, Speth BM, et al. Synovial sarcomas usually metastasize after > 5 years: a multicenter retrospective analysis with minimum follow-up of 10 years for survivors. Ann Oncol 2011; 22:458–467
13. Perlmutter AE, Saunders SE, Zaslau S, Chang WW, Farivar-Mohseni H. Primary synovial sarcoma of the kidney. Int J Urol 2005; 12:760–762
14. Jaques DP, Coit DG, Casper ES, Brennan MF. Hepatic metastases from soft-tissue sarcoma. Ann Surg 1995; 221:392–397
15. Singer S, Baldini EH, Demetri GD, Fletcher JA, Corson JM. Synovial sarcoma: prognostic significance of tumor size, margin of resection, and mitotic activity for survival. J Clin Oncol 1996; 14:1201–1208
16. Eilber FC, Dry SM. Diagnosis and management of synovial sarcoma. J Surg Oncol 2008; 97:314–320
17. Skinner KA, Eilber FR: Soft tissue sarcoma nodal metastases: Biologic significance and therapeutic considerations. Surg Oncol Clin N Am 1996;5:121–127.
18. Trassard M, Le Doussal V, Hacene K, et al.: Prognostic factors in localized primary synovial sarcoma: A multicenter study of 128 adult patients. J Clin Oncol 2001;19:525–534.
19. Guillou L, Benhattar J, Bonichon F, et al.: Histologic grade, but not SYT-SSX fusion type, is an important prognostic factor in patients with synovial sarcoma: A multicenter, retrospective analysis. J Clin Oncol 2004;22:4040–4050.
20. Hasegawa T, Yamamoto S, Yokoyama R, et al.: Prognostic significance of grading and staging systems using MIB-1 score in adult patients with soft tissue sarcoma of the extremities and trunk. Cancer 2002;95:843–851.
21. Guillou L, Coindre JM, Bonichon F, et al.: Comparative study of the National Cancer Institute and French Federation of Cancer Centers Sarcoma Group grading systems in a population of 410 adult patients with soft tissue sarcoma. J Clin Oncol 1997;15: 350–362.
22. Hasegawa T, Yokoyama R, Matsuno Y, et al.: Prognostic significance of histologic grade and nuclear expression of betacatenin in synovial sarcoma. Hum Pathol 2001;32:257–263.
23. Weiss SW, Goldblum J, Malignant soft tissue tumors of uncertain type. In: Weiss SW, Goldblum JR, editors. Enzinger and Weiss’s soft tissue tumors. CV Mosby: St. Louis; 2001. pp 1483–1571.
24. Fletcher CD, Unni KK, Mertens F, editors. Pathology and genetics of tumours of the soft tissues and bones. World Health Organization Classification of Tumours. Lyon: W.H. Organization; 2003.
25. Rosen G, Forscher C, Lowenbraun S, et al.: Synovial sarcoma: Uniform response of metastases to high dose ifosfamide. Cancer 1994;73:2506–2511.
26. Kampe CE, Rosen G, Eilber F, et al.: Synovial sarcoma: A study of intensive chemotherapy in 14 patients with localized disease. Cancer 1993;72:2161–2169.
27. Landenstein R, Treuner J, Koscielniak E, et al.: Synovial sarcoma of childhood and adolescence: Report of the German CWS-81 study. Cancer 1993;71:3647–3655.
28. Okcu MF, Munsell M, Treuner J, et al.: Synovial sarcoma of childhood and adolescence: A multicenter, multivariate analysis of outcome. J Clin Oncol 2003;21:1602–1611.
29. Spurrell EL, Fisher C, Thomas M, et al.: Prognostic factors in advanced synovial sarcoma: An analysis of 104 patients treated at the Royal Marsden Hospital. Ann Oncol 2005;16:437–444.
30. Brodowicz T, Schwameis E, Widder J, et al.: Intensified adjuvant IFADIC chemotherapy for adult soft tissue sarcoma: A prospective randomized feasibility trial. Sarcoma 2000;4:151–160.
31. Gortzak E, Azzarelli A, Buesa J, et al.: A randomized phase II study on neo-adjuvant chemotherapy for ‘‘high-risk’’ adult softtissue sarcoma. Eur J Cancer 2001;37:1096–1103.
Published
2024-05-21
How to Cite
Hajri, A., Jamaleddine, K., El Wassi, A., Erguibi, D., Boufettal, R., Jai Rifki, S., & Chehab, F. (2024). Intra-abdominal metastasis after pelvic primary Synovial Sarcoma resection: case report. European Scientific Journal, ESJ, 29, 539. Retrieved from https://eujournal.org/index.php/esj/article/view/18157
Section
ESI Preprints
Copyright (c) 2024 Amal Hajri, Khalid Jamaleddine, Anas El Wassi, Driss Erguibi, Rachid Boufettal, Saad Jai Rifki, Farid Chehab
This work is licensed under a Creative Commons Attribution 4.0 International License.
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