DESIGN, DEVELOPMENT AND EVALUATION OF FENOFIBRATE AND ROSUVASTATIN NANODROPLETS

  • Raman Suresh Kumar Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund (A constituent college of JSS University, Mysore), The Nilgiris, Tamilnadu, India
DOI: https://doi.org/10.19044/esj.2013.v9n10p%25p

Abstract

Fibrate and statin combinational therapy is used to treat severe and refractory mixed hyperlipidemia. Hence lipid based SNEDDS were prepared using the concentration oil (2:1) and SCoS (1:1) which resulted in enhanced extent of absorption and relative bioavailability of 1.69 (fibrate) and 1.64 (statin). An approximately 40% of drug was available for systemic circulation via lymphatic route of absorption. The results showed a significant difference between the marketed and the SNEDDS

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Published
2014-01-14
How to Cite
Kumar, R. S. (2014). DESIGN, DEVELOPMENT AND EVALUATION OF FENOFIBRATE AND ROSUVASTATIN NANODROPLETS. European Scientific Journal, ESJ, 9(10). https://doi.org/10.19044/esj.2013.v9n10p%p
Issue
ESJ December 2013 /SPECIAL/ edition Vol.4
Section
Articles