CLINICAL AND BIOCHEMICAL CHARACTERISTICS IN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME IN THE REGION OF POLLOG, REPUBLIC OF MACEDONIA

Abstract

Polycystic ovary syndrome (PCOS) is a common endocrine disorderand is a major cause of an ovulatory infertility. The main objective is toestimate the prevalence of PCOS in the region of Pollog, Republic ofMacedonia and to assess some clinical and biochemical parameters inpatients with PCOS in comparison with normal women as control.Rotterdam criteria is used to evaluate 70 women diagnosed with PCOS,compared to 30 age matched controls to assess the clinical and biochemicalabnormalities that occur in PCOS patients. All statistical analysis is doneusing SPSS (version 19.0). A P-value < 0.05 is considered statisticallysignificant. Mean age in PCOS group is 25.11 ± 3.32, and 25.10 ± 3.91 in thecontrol group. BMI of the women with PCOS is significantly higher than inthe control group. Menstrual cycle abnormalities are observed in 71.4% ofPCOS patients, and ultrasonographic appearance of polycystic ovaries isreported for all PCOS cases. Hirsutism (FG 8-9) is present in 42.9 %,hirsutism (FG 10-14) in 50% and 7.1% showed hirsutism (FG>15). Werecorded significantly higher serum levels of luteinizing hormone (LH), totaltestosterone (TT), and insulin, while the serum levels of sex hormonebinding globuline (SHBG) and follicular stimulating hormone (FSH) aresignificantly lower than in the control group. By analyzing the clinical andbiochemical characteristics of our studied population of patients with PCOS,we can conclude that the majority of our patients expressed all threediagnostic features of PCOS (hyperandrogenism, menstrual abnormalities,and ultrasound findings of polycystic ovaries).