ASSESSMENT OF IMMUNE STABILITY IN BREAST CANCER SUBJECTS

  • Oluboyo A.O Department of Medical Laboratory Science, Faculty of Health Sciences and Technology, College of Health Sciences, Nnamdi Azikiwe, University, Nnewi Campus, Anambra State, Nigeria
  • Meludu S.C Department of Human Biochemistry, Faculty of Basic Medical Sciences, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria
  • Onyenekwe C.C Department of Medical Laboratory Science, Faculty of Health Sciences and Technology, College of Health Sciences, Nnamdi Azikiwe, University, Nnewi Campus, Anambra State, Nigeria
  • Oluboyo B.O Molecular Diagnostic Laboratory, Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi, Anambra State, Nigeria
  • Chianakwanam G.U Surgical Out patients’ Department, Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi, Anambra State, Nigeria
  • Emegakor C Surgical Out patients’ Department, Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi, Anambra State, Nigeria

Abstract

Cancer is a cause of death worldwide and the socio-economic impact of cancer is enormous and disturbing. Breast cancer is becoming a significant health concern for women across Nigeria and immune instability may be responsible. Therefore, the present study was designed to assess the immune stability of breast cancer subjects using CD4 + T cell, CD8 + T cell counts and the CD4/CD8 ratio. One hundred subjects were randomly recruited for the study and grouped into Breast cancer subjects (BCA) (n=50) and control (n=50). CD4 + T cells (μl/count) and CD8 + T cells (μl/count) were estimated using flow cytometric method while CD4/CD8 ratio was calculated from the values obtained from the CD4 + T cells and CD8 + T cells. CD4+ T cells and CD8+ T cells showed significant decrease (p<0.05) in the breast cancer subjects compared to the control subjects. The suppressed CD4 + and CD8 + T cell counts in breast cancer subjects mayindicate immune instability in the cancer subjects.

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Published
2014-09-29
How to Cite
A.O, O., S.C, M., C.C, O., B.O, O., G.U, C., & C, E. (2014). ASSESSMENT OF IMMUNE STABILITY IN BREAST CANCER SUBJECTS. European Scientific Journal, ESJ, 10(27). https://doi.org/10.19044/esj.2014.v10n27p%p