Assessment of Radical Scavenging and Sickling Inhibitory Activities of the Bark of Disthemonanthus Benthamianus (Caesalpiniaceae)

  • Akakpo-Akue Joël Laboratory of Biology and Health, UFR Biosciences, University Félix Houphouët-Boigny (UFHB), Côte d’Ivoire
  • Ahon Gnamien Marcel Laboratory of Biology and Health, UFR Biosciences, University Félix Houphouët-Boigny (UFHB), Côte d’Ivoire
  • Kplé Tatiana Kangah Mireille Laboratory of Biology and Health, UFR Biosciences, University Félix Houphouët-Boigny (UFHB), Côte d’Ivoire Immunity Biology Center, Institute Pasteur of Côte d’Ivoire, Côte d’Ivoire
  • Fofié Yvette Pharmacognosy Laboratory, UFR of Pharmaceutical and Biological Sciences, University Félix Houphouët-Boigny, Côte d’Ivoire
  • Ibrahime Sanogo Clinical Haematology Department, University Hospital of Yopougon, Abidjan, Côte d’Ivoire
  • Yapo-Crezoit Antoinette Claire Chiyae Immunity Biology Center, Institute Pasteur of Côte d’Ivoire, Côte d’Ivoire
  • Kra Adou Koffi Mathieu Laboratory of Biology and Health, UFR Biosciences, Université Félix Houphouët-Boigny (UFHB), Côte d’Ivoire
Keywords: Disthemonanthus benthamianus, phenolic compounds, antioxidant activity, antisickling activity, Côte d’Ivoire

Abstract

Among the medicinal plants used in the treatment of sickle cell disease in south-east of Côte d'Ivoire is Disthemonanthus benthamianus. This paper focuses on assessing its antioxidant properties and its antisickling activity. The test of inhibition of sodium metabisulfite-induced sickling of the erythrocytes was carried out based on this evaluation. The total phenolic compounds contents were 45 ± 0.64 and 39.84 ± 0.69 mg/g of dry weight for ethanolic extract and the decocted respectively. The DPPH reduction test showed that the decocted (9 μg/mL) had a lower IC50 than the ethanolic extract (16 μg/mL). There was no significant difference between the sickling inhibitory activities of the ethanolic extract (87.00%) and the decocted (81.66%). This study showed that both extracts had sickling inhibitory and antioxidant activities.

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Published
2021-03-31
How to Cite
Joël, A.-A., Marcel, A. G., Kangah Mireille , K. T., Yvette, F., Sanogo, I., Claire Chiyae, Y.-C. A., & Koffi Mathieu, K. A. (2021). Assessment of Radical Scavenging and Sickling Inhibitory Activities of the Bark of Disthemonanthus Benthamianus (Caesalpiniaceae). European Scientific Journal, ESJ, 17(10), 121. https://doi.org/10.19044/esj.2021.v17n10p121
Section
ESJ Natural/Life/Medical Sciences