Antioxidant And Anti-Inflammatory Effects Of Ethanolic And Aqueous Root Extracts Of Piliostigma Thonningii (Schumach.) Milne-Redhead
Keywords:
Piliostigma Thonningii
Abstract
Piliostigma thonningii is a tree with many ethnomedical and medico-religious uses. In Ivory Coast the roots associated with the leaves are used as an antidote for snakebites and for the treatment of gonorrhea and rheumatism. 2,2-Diphenyl 1-picrylhydrazyl is a free radical. This compound is used to measure the antioxidant activity of a plant by its ability to scavenge free radicals from DPPH. Antioxidants help protect our body against free radicals and thus prevent many diseases. The pharmacological importance of Piliostigma thonningii seems to be ignored by a large part of the population. The study of anti-inflammatory activity in vivo which consists of provoking an acute inflammation induced in rats by injection of carrageenan. AEPT and EEPT show significant anti-inflammatory activity. They very significantly inhibit the development of paw edema induced by carrageenan. They significantly reduce the recruitment of immune cells to the inflammatory site. Piliostigma thonningii extracts work by blocking the formation of prostaglandins, the substances responsible for inflammation. The results of study suggest that Piliostigma thonningii possess some antioxidant properties and provide relief against inflammation making it a possible future therapy for inflammation.
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19. Li, F., Huo, J., Zhuang, Y., Xiao, H., Wang, W., & Huang, L. (2020). Anti-nociceptive and anti-inflammatory effects of the ethanol extract of Arenga pinnata (Wurmb) Merr. fruit. Journal of ethnopharmacology, 248, 112349. https://doi.org/10.1016/j.jep.2019.112349
20. Liu, N., Zhang, G. X., Niu, Y. T., Wang, Q., Zheng, J., Yang, J. M., Sun, T., Niu, J. G., & Yu, J. Q., (2020). Anti-inflammatory and analgesic activities of indigo through regulating the IKKβ/IκB/NF-κB pathway in mice. Food & fun
2. Azab, A., Nassar, A., & Azab, A. N. (2016). Anti-Inflammatory Activity of Natural Products. Molecules (Basel, Switzerland), 21(10), 1321. https://doi.org/10.3390/molecules21101321
3. Afolayan, M., Srivedavyasasri, R., Asekun, O. T., Familoni, O. B., Orishadipe, A., Zulfiqar, F., Ibrahim, M. A., & Ross, S. A. (2018). Phytochemical study of Piliostigma thonningii, a medicinal plant grown in Nigeria. Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents, 27(10), 2325-2330. https://doi.org/10.1007/s00044-018-2238-1
4. Ighodaro O. M, Agunbiade S. O, Omole J. O, Kuti O. A. (2012). Evaluation of the chemical, nutritional, antimicrobial and antioxidantvitamin profiles of Piliostigma thonningii leaves (Nigerian species). Research Journal of Medicinal Plants, 6: 537-543. https://doi.org/10.3923/rjmp.2012.537.543
5. Sylla T., Mahe M. J., & Dongui B. K. (2021). Acute oral toxicity, analgesic effect and healing activity of the root’s extracts of Strophanthus gratus (Wall. & Hook.) Baill. Journal of Medicinal Plants Studies, 9(6), 37-42. https://doi.org/10.22271/plants.2021.v9.i6a.1350
6. Valan M. F., & Oladimeji A. V. (2021) Standardization and Phytochemical Screening activity of Abrus Precatorius Linn Root Extracts. Natural Products Chemistry & Research. 9:1. https://doi.org/10.35248/2329-6836.21.9.395
7. Sinan, K. I., Ak, G., Etienne, O. K., Jekő, J., Cziáky, Z., Gupcsó, K., João Rodrigues, M., Custodio, L., Mahomoodally, M. F., Sharmeen, J. B., Brunetti, L., Leone, S., Recinella, L., Chiavaroli, A., Orlando, G., Menghini, L., Tacchini, M., Ferrante, C., & Zengin, G. (2021). Deeper Insights on Alchornea cordifolia (Schumach. & Thonn.) Müll.Arg Extracts: Chemical Profiles, Biological Abilities, Network Analysis and Molecular Docking. Biomolecules, 11(2), 219. https://doi.org/10.3390/biom11020219
8. Owolabi, O. O., James, D. B., Sani, I., Andongma, B. T., Fasanya, O. O., & Kure, B. (2018). Phytochemical analysis, antioxidant and anti-inflammatory potential of FERETIA APODANTHERA root bark extracts. BMC complementary and alternative medicine, 18(1), 12. https://doi.org/10.1186/s12906-017-2070-z
9. Meshram, G. G., Kumar, A., Rizvi, W., Tripathi, C. D., & Khan, R. A. (2015). Evaluation of the anti-inflammatory activity of the aqueous and ethanolic extracts of the leaves of Albizzia lebbeck in rats. Journal of traditional and complementary medicine, 6(2), 172-175. https://doi.org/10.1016/j.jtcme.2014.11.038
10. Ahmadiani, A., Hosseiny, J., Semnanian, S., Javan, M., Saeedi, F., Kamalinejad, M., & Saremi, S. (2000). Antinociceptive and anti-inflammatory effects of Elaeagnus angustifolia fruit extract. Journal of ethnopharmacology, 72(1-2), 287-292. https://doi.org/10.1016/s0378-8741(00)00222-1
11. Okwu, D. E., & Emenike, I. N. (2006). Evaluation of The Phytonutrients and Vitamins Content of Citrus Fruits. International Journal of Molecular Medicine and Advance Sciences, 2: 1-6. https://medwelljournals.com/abstract/?doi=ijmmas.2006.1.6
12. Tion, M. T., Fotina, H., & Saganuwan, S. A. (2018). Phytochemical screening, proximate analysis, median lethal dose (LD50), hematological and biochemical effects of various extracts of Abrus precatorius seeds in Mus musculus. Journal of Advanced Veterinary and Animal Research, 5(3), 354–360. Retrieved from https://www.banglajol.info/index.php/JAVAR/article/view/38441
13. Beretta, G., Rossoni, G., Santagati, N. A., & Facino, R. M. (2009). Anti-ischemic activity and endothelium-dependent vasorelaxant effect of hydrolysable tannins from the leaves of Rhus coriaria (Sumac) in isolated rabbit heart and thoracic aorta. Planta medica, 75(14), 1482–1488. https://doi.org/10.1055/s-0029-1185797
14. Eleazu C. O., Okafor P. N., Amajor J., Awa E., Ikpeama A. I., Eleazu K. C. (2011) Chemical composition,antioxidant activity, functional properties and inhibitory action of unripe plantain (M. Paradisiacae) flour. Afr J Biotechnol. 10(74):16948-16952.
https://doi.org/10.5897/AJB10.1180
15. Pattanayak S. P., Mazumder P. M., Sunita P. (2012) Total phenolic content, flavonoid content and in vitro antioxidant activities of Dendrophthoe falcata (L.f.) Ettingsh. Research Journal of Medicinal Plant. 6:136-148. https://doi.org/10.3923/rjmp.2012.136.148
16. Azazahemad K., Amit M., Siddhesh S., Premlata K., Raghuraj S. and Satyanshu K. (2020). Antioxidant Activities and Phenolics Contents of Garcinia talbotii Fruit Rind. Research Journal of Medicinal Plants, 14: 104-110. https://doi.org/10.3923/rjmp.2020.104.110
17. Morais, M. G., Saldanha, A. A., Costa Rodrigues, J. P., Cotta Mendes, I., Ferreira, L. M., Avelar Amado, P., de Souza Farias, K., Samúdio Santos Zanuncio, V., Brentan da Silva, D., Carmo Horta Pinto, F., Soares, A. C., & Alves Rodrigues Dos Santos Lima, L. (2020). Chemical composition, antioxidant, anti-inflammatory and antinociceptive activities of the ethanol extract of ripe fruits of Solanum lycocarpum St. Hil. (Solanaceae). Journal of ethnopharmacology, 262, 113125. https://doi.org/10.1016/j.jep.2020.113125
18. Graczyk, M., Lewandowska, A. A., & Dzierżanowski, T. (2021). The Therapeutic Potential of Cannabis in Counteracting Oxidative Stress and Inflammation. Molecules (Basel, Switzerland), 26(15), 4551. https://doi.org/10.3390/molecules26154551
19. Li, F., Huo, J., Zhuang, Y., Xiao, H., Wang, W., & Huang, L. (2020). Anti-nociceptive and anti-inflammatory effects of the ethanol extract of Arenga pinnata (Wurmb) Merr. fruit. Journal of ethnopharmacology, 248, 112349. https://doi.org/10.1016/j.jep.2019.112349
20. Liu, N., Zhang, G. X., Niu, Y. T., Wang, Q., Zheng, J., Yang, J. M., Sun, T., Niu, J. G., & Yu, J. Q., (2020). Anti-inflammatory and analgesic activities of indigo through regulating the IKKβ/IκB/NF-κB pathway in mice. Food & fun
Published
2022-01-31
How to Cite
Tahiri, S., & Bini Kouamé, D. (2022). Antioxidant And Anti-Inflammatory Effects Of Ethanolic And Aqueous Root Extracts Of Piliostigma Thonningii (Schumach.) Milne-Redhead. European Scientific Journal, ESJ, 18(3), 101. https://doi.org/10.19044/esj.2022.v18n3p101
Section
ESJ Natural/Life/Medical Sciences
Copyright (c) 2022 Sylla Tahiri, Dongui Bini Kouamé
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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