Lavendula Angustifolia, Rosmarinus Officinalis, Thymus Serpyllum and Origanum rotundifolium: Exploring natural solutions for inflammation and blood sugar management
Keywords:
Lamiaceae Family, anti-diabetic activity, Antioxidant potential, Anti-inflammatory properties
Abstract
The Lamiaceae family, including common herbs like rosemary and mint, is being investigated for its potential health benefits. In addition to numerous health benefits, research is looking into these plants' anti-inflammatory qualities and potential impacts on blood sugar regulation. More specifically, the Greek endemic Lamiaceae plants are proven to be of great importance, regarding their bioactive compounds and the antioxidant, antidiabetic, and anti-inflammatory properties they have. Researchers are interested in understanding how Lamiaceae plant compounds might work in the body. Besides, Antioxidants have an increasingly important function in reducing tissue damage and cytotoxicity caused by hydrogen peroxide and oxygen radicals in a variety of human disorders. This knowledge could lead to the development of natural approaches for managing inflammation and potentially even diabetes. These plant-based options may offer a milder alternative to some conventional medications. By supporting the body's natural regulatory systems, Lamiaceae plants could contribute to a more holistic approach to well-being. This study's objective was to review the literature on the anti-inflammatory, antidiabetic, and antioxidant properties of the Lamiaceae species Lavendula Angustifolia, Rosmarinus Officinalis, Thymus Serpyllum, and Origanum rotundifolium
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References
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21. Mengoni ES, Vichera G, Rigano LA, Rodriguez-Puebla ML. Suppression of COX-2, IL-1β and TNF-α expression and leukocyte infiltration in inflamed skin by bioactive compounds from Rosmarinus officinalis L. Fitoterapia. 82(3):414-421 (2011).
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24. Salaria D, Rolta R, Lal UR, Dev K, Kumar V.A comprehensive review on traditional applications, phytochemistry, pharmacology, and toxicology of Thymus serpyllum. Indian J Pharmacol. 55(6):385-394 (2023). doi: 10.4103/ijp.ijp_220_22. PMID: 38174535; PMCID: PMC10821696
25. Alamgeer, M. "Evaluation of Hypoglycemic activity of Thymus serpyllum Linn in glucose treated mice." International Journal of Basic Medical Sciences and Pharmacy (IJBMSP) 3(2) (2014)
26. Picos-Salas M., Heredia J., Leyva-López N., Ambriz-Pérez D., Gutiérrez-Grijalva Gutiérrez- Grijalva E. Extraction Processes Affect the Composition and Bioavailability of Flavones from Lamiaceae Plants: A Comprehensive Review. Processes 9:1675 (2021). https://doi.org/ 10.3390/pr9091675
27. Maietta M., Colombo R., Corana F., Papetti A. Cretan tea (Origanum dictamnus L.) as a functional beverage: An investigation on antiglycative and carbonyl trapping activities. Food Funct. 9: 1545–1556 (2018).
28. Leyva-Lopez N., Gutiérrez-Grijalva E.P., Vazquez-Olivo G., Heredia J.B. Essential oils of oregano: Biological activity beyond their antimicrobial properties. Molecules. 22(6), 989 (2017). https://doi.org/10.3390/molecules22060989.
29. Leyva-López N, Gutiérrez-Grijalva EP, Vazquez-Olivo G, Heredia JB. Essential Oils of Oregano: Biological Activity beyond Their Antimicrobial Properties. Molecules. 14; 22(6):989 (2017). doi: 10.3390/molecules22060989. PMID: 28613267; PMCID: PMC6152729
30. Aras A., Silinsin M., Bingol, MN., Bursal E., Identification of bioactive polyphenolic compounds and assessment of antioxidant activity of Origanum acutidens. ILNS. 66:1-8 (2017).
https://www.who.int/health-topics/diabetes
2. Trapali M. Antioxidant Activity in Patients with Type II Diabetes. Review of Clinical Pharmacology and Pharmacokinetics, 36(1):6 (2022)
3. Trapali M., Papadopoulou A. Genetic polymorphisms possibly implicated in Diabetes Mellitus. Review of Clinical Pharmacology and Pharmacokinetics, 37(1): 1-6 (2023)
4. Trapali M. Oxidic degradation of lipids in patients with type II diabetes. Review of Clinical Pharmacology and Pharmacokinetics, 35(2): 4 (2021)
5. Bourkoula A., Konsta E., Papadopoulou A., Trapali M. Lipidic classes involved in Diabetes mellitus. Review Nov Res Sci. NRS. 000685 (2021) DOI: 10.31031/NRS.2021.08.000685
6. Ma B, Whiteford JR, Nourshargh S, Woodfin A. Underlying chronic inflammation alters the profile and mechanisms of acute neutrophil recruitment. J Pathol. 240(3):291-303 (2016). doi: 10.1002/path.4776.
7. Pizzino G, Irrera N, Cucinotta M, Pallio G, Mannino F, Arcoraci V, Squadrito F, Altavilla D, Bitto A. Oxidative Stress: Harms and Benefits for Human Health. Oxid Med Cell Longev. 8416763 (2017). doi: 10.1155/2017/8416763.
8. Letsiou, S., Trapali, M., Tebbi, S.O., Benaida-Debbache, N.A simple and robust LC-ESI single quadrupole MS-based method to analyze polyphenols in plant extracts using deep eutectic solvents. MethodsX. 11: 102303 (2023)
9. Letsiou, S., Trapali, M., Vougiouklaki, D., Tsakni A. Antonopoulos, D., Houhoula, D. Antioxidant Profile of Origanum dictamnus L. exhibits Antiaging Properties against UVA Irradiation Cosmetics. 10(5), 124 (2023) https://doi.org/10.3390/cosmetics10050124
10. Tebbi, S.O., Trapali, M., Letsiou, S. Exploring the Anti-Diabetic, Antioxidant and Anti-Microbial Properties of Clematis flammula L. Leaves and Pistacia lentiscus L. Fruits Using Choline Chloride-Based Deep Eutectic Solvent Waste and Biomass Valorization, (2023) https://doi.org/10.1007/s12649-023-02360-9
11. Habán M., Korczyk-Szabó J., Certekov S., Ražná K. Lavandula Species, Their Bioactive Phytochemicals, and Their Biosynthetic Regulation. Int. J. Mol. Sci. 24: 8831 (2023). https://doi.org/ 10.3390/ijms24108831
12. Hajhashemi V, Ghannadi A, Sharif B. Anti-inflammatory and analgesic properties of the leaf extracts and essential oil of Lavandula angustifolia Mill. J Ethnopharmacol. 89(1):67-71(2023). doi: 10.1016/s0378-8741(03)00234-4.
13. Dobros N., Zawada KD., Paradowska, K., Phytochemical profiling, antioxidant and anti-inflammatory activity of plants belonging to the Lavandula genus. Molecules. 28(1),256 (2023). https://doi.org/10.3390/molecules28010256
14. Batiha, GE., Teibo, J.O., Wasef, L., Shaeen, H.M., Akomolafe, A.P., Teibo, T.K.A., Al-Kuraishy, H.M., Al-Garbeeb. A., Alexiou, A., Papadakis, M. A review of the bioactive components and pharmagological properties of Lavandula species. https://doi.org/10.1007/s00210-023-02392-x. (2023)
15. Issa A., Mohammad M., Hudaib M., Bustanji Y. A potential role of Lavandula angustifolia in the management of diabetic dyslipidemia. Journal of Medicinal Plants Research 5(16):3876-3882(2011)
16. Akshay K., Swathi K., Bakshi V., Boggula N. Rosmarinus officinalis L. an update review of its phytochemistry and biological activity. JDDT. 9(1): 323-330 (2019). http://dx.doi.org/10.22270/jddt.v9i1.2218.
17. Bakirel T, Bakirel U, Keleş OU, Ülgen SG, Yardibi H. In vivo assessment of antidiabetic and antioxidant activities of rosemary (Rosmarinus officinalis) in alloxan-diabetic rabbits. Journal of Ethnopharmacology. 116(1):64-73 (2008)
18. Abu-Al-Basal MA. Healing potential of Rosmarinus officinalis L. on full-thickness excision cutaneous wounds in alloxan- diabetic BALB/c mice. Journal of Ethnopharmacology. 131(2):443-450 (2010).
19. Khalil OA, Ramadan KS, Danial EN, Alnahdi HS, Ayaz NO. Antidiabetic activity of Rosmarinus officinalis and its relationship with the antioxidant property. African Journal of Pharmacy and Pharmacology. 6(14):1031-1036 (2012).
20. de Oliveira JR, Camargo SEA, de Oliveira LD. Rosmarinus officinalis L. (rosemary) as therapeutic and prophylactic agent J Biomed Sci. 9;26(1):5 (2019). doi: 10.1186/s12929-019-0499-8. PMID: 30621719; PMCID: PMC6325740
21. Mengoni ES, Vichera G, Rigano LA, Rodriguez-Puebla ML. Suppression of COX-2, IL-1β and TNF-α expression and leukocyte infiltration in inflamed skin by bioactive compounds from Rosmarinus officinalis L. Fitoterapia. 82(3):414-421 (2011).
22. Benincá JP, Dalmarco JB, Pizzolatti MG, Fröde TS. Analysis of the anti-inflammatory properties of Rosmarinus officinalis L. in mice. Food Chemistry. 124:468-475 (2011).
23. 24.Gaya M, Repetto V, Toneatto J, Anesini C, Piwien -Pilipuk G. Antiadipogenic effect of carnosic acid, a natural compound present in Rosmarinus officinalis, is exerted through the C/EBPs and PPARγ pathways at the onset of the differentiation program. Biochimica et Biophysica Acta. 1830(6):3796- 3806 (2013)
24. Salaria D, Rolta R, Lal UR, Dev K, Kumar V.A comprehensive review on traditional applications, phytochemistry, pharmacology, and toxicology of Thymus serpyllum. Indian J Pharmacol. 55(6):385-394 (2023). doi: 10.4103/ijp.ijp_220_22. PMID: 38174535; PMCID: PMC10821696
25. Alamgeer, M. "Evaluation of Hypoglycemic activity of Thymus serpyllum Linn in glucose treated mice." International Journal of Basic Medical Sciences and Pharmacy (IJBMSP) 3(2) (2014)
26. Picos-Salas M., Heredia J., Leyva-López N., Ambriz-Pérez D., Gutiérrez-Grijalva Gutiérrez- Grijalva E. Extraction Processes Affect the Composition and Bioavailability of Flavones from Lamiaceae Plants: A Comprehensive Review. Processes 9:1675 (2021). https://doi.org/ 10.3390/pr9091675
27. Maietta M., Colombo R., Corana F., Papetti A. Cretan tea (Origanum dictamnus L.) as a functional beverage: An investigation on antiglycative and carbonyl trapping activities. Food Funct. 9: 1545–1556 (2018).
28. Leyva-Lopez N., Gutiérrez-Grijalva E.P., Vazquez-Olivo G., Heredia J.B. Essential oils of oregano: Biological activity beyond their antimicrobial properties. Molecules. 22(6), 989 (2017). https://doi.org/10.3390/molecules22060989.
29. Leyva-López N, Gutiérrez-Grijalva EP, Vazquez-Olivo G, Heredia JB. Essential Oils of Oregano: Biological Activity beyond Their Antimicrobial Properties. Molecules. 14; 22(6):989 (2017). doi: 10.3390/molecules22060989. PMID: 28613267; PMCID: PMC6152729
30. Aras A., Silinsin M., Bingol, MN., Bursal E., Identification of bioactive polyphenolic compounds and assessment of antioxidant activity of Origanum acutidens. ILNS. 66:1-8 (2017).
Published
2024-07-18
How to Cite
Lagouri, V., Tebbi, S. O., Caseiro, A., & Trapali, M. (2024). Lavendula Angustifolia, Rosmarinus Officinalis, Thymus Serpyllum and Origanum rotundifolium: Exploring natural solutions for inflammation and blood sugar management. European Scientific Journal, ESJ, 31, 287. Retrieved from https://eujournal.org/index.php/esj/article/view/18342
Section
ESI Preprints
Copyright (c) 2024 Vasiliki Lagouri, Sara Oumenoune Tebbi, Armando Caseiro, Maria Trapali
This work is licensed under a Creative Commons Attribution 4.0 International License.
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