Lamiaceae Family Plants as Natural Solutions for Inflammation and Blood Sugar Management
Keywords:
Lamiaceae Family, anti-diabetic activity, Antioxidant potential, Anti-inflammatory properties
Abstract
The Lamiaceae family, including common herbs like rosemary and mint, is being investigated for its potential health benefits. In addition to numerous health benefits, research is looking into these plants' anti-inflammatory qualities and potential impacts on blood sugar regulation. More specifically, the Greek endemic Lamiaceae plants are proven to be of great importance, regarding their bioactive compounds and the antioxidant, antidiabetic and anti-inflammatory properties they have. The study's objective was to compile information from the literature regarding the anti-inflammatory, antidiabetic, and antioxidant properties of Origanum rotundifolium, Rosmarinus officinalis, Lavendula angustifolia, and Thymus serpyllum. Lavender angustifolia is used for many traditional medical and cosmetic products. Several studies demonstrated strong anti-inflammatory mechanisms exhibited by Rosmarinus officinalis. Leukocyte migration was found to be significantly inhibited in vivo by rosemary essential oil and extract. Changes in the gut microbiota induced by essential oils rosemary as prebiotics in mice regulated cardiovascular and metabolic factors, which focus on the potential of these nutraceuticals for reducing Ischemic heart disease risk in patients affected by type-2 diabetes mellitus. A mixture of Origanum majorana and Origanum vulgare plants investigated antidiabetic activities in zebrafish. The Lamiaceae family provides a natural source of substances that may be used in functional foods. These functional meals have the potential to improve general health and help manage chronic illnesses. The precise mechanisms of action of these plants and the best doses for use in functional food applications require more investigation.
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References
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2. Abu-Al-Basal, M. A. (2010). Healing potential of *Rosmarinus officinalis* L. on full-thickness excision cutaneous wounds in alloxan-diabetic BALB/c mice. *Journal of Ethnopharmacology*, 131(2), 443-450.
3. Ahmed, H. M., & Babakir-Mina, M. (2020). Investigation of rosemary herbal extracts (*Rosmarinus officinalis*) and their potential effects on immunity. *Phytotherapy Research*, 34(8), 1829-1837. https://doi.org/10.1002/ptr.6648
4. Akshay, K., Swathi, K., Bakshi, V., & Boggula, N. (2019). *Rosmarinus officinalis* L.: An updated review of its phytochemistry and biological activity. *Journal of Drug Delivery and Therapeutics*, 9(1), 323-330. http://dx.doi.org/10.22270/jddt.v9i1.2218
5. Alamgeer, M. (2014). Evaluation of hypoglycemic activity of *Thymus serpyllum* Linn in glucose-treated mice. *International Journal of Basic Medical Sciences and Pharmacy (IJBMSP)*, 3(2).
6. Aras, A., Silinsin, M., Bingol, M. N., & Bursal, E. (2017). Identification of bioactive polyphenolic compounds and assessment of antioxidant activity of *Origanum acutidens*. *International Letters of Natural Sciences*, 66, 1-8.
7. Azhar, J., John, P., & Bhatti, T. (2022). *Thymus serpyllum* exhibits anti-diabetic potential in streptozotocin-induced diabetes mellitus type 2 mice: A combined biochemical and in vivo study. *Nutrients*, 14(17), 3561. https://doi.org/10.3390/nu14173561
8. Bakirel, T., Bakirel, U., Keleş, O. U., Ülgen, S. G., & Yardibi, H. (2008). In vivo assessment of antidiabetic and antioxidant activities of rosemary (*Rosmarinus officinalis*) in alloxan-diabetic rabbits. *Journal of Ethnopharmacology*, 116(1), 64-73.
9. Batiha, G. E., Teibo, J. O., Wasef, L., Shaeen, H. M., Akomolafe, A. P., Teibo, T. K. A., Al-Kuraishy, H. M., Al-Garbeeb, A., Alexiou, A., & Papadakis, M. (2023). A review of the bioactive components and pharmacological properties of *Lavandula* species. *Naunyn-Schmiedeberg's Archives of Pharmacology*, 396(4), 1-24. https://doi.org/10.1007/s00210-023-02392-x
10. Benincá, J. P., Dalmarco, J. B., Pizzolatti, M. G., & Fröde, T. S. (2011). Analysis of the anti-inflammatory properties of *Rosmarinus officinalis* L. in mice. *Food Chemistry*, 124, 468-475.
11. Bhattarai, N., Kumbhar, A. A., Pokharel, Y. R., & Yadav, P. N. (2021). Anticancer potential of coumarin and its derivatives. *Mini Reviews in Medicinal Chemistry*, 21(19), 2996-3029. https://doi.org/10.2174/1389557521666210405160323
12. Bourkoula, A., Konsta, E., Papadopoulou, A., & Trapali, M. (2021). Lipidic classes involved in diabetes mellitus. *Novel Research in Sciences*, 8(2), NRS.000685. https://doi.org/10.31031/NRS.2021.08.000685
13. But, V. M., Bulboacă, A. E., Rus, V., Ilyés, T., Gherman, M. L., & Bolboacă, S. D. (2023). Anti-inflammatory and antioxidant efficacy of lavender oil in experimentally induced thrombosis. *Thrombosis Journal*, 21(1), Article 85. https://doi.org/10.1186/s12959-023-00516-0
14. De Oliveira, J. R., Camargo, S. E. A., & de Oliveira, L. D. (2019). *Rosmarinus officinalis* L. (rosemary) as therapeutic and prophylactic agent. *Journal of Biomedical Science*, 26(1), Article 5. https://doi.org/10.1186/s12929-019-0499-8
15. Dimopoulos, P., Raus, T., Bergmeier, E., Constantinidis, T., Iatrou, G., Kokkini, S., Strid, A., & Tzanoudakis, D. (2013). *Vascular plants of Greece: An annotated checklist*. Botanic Garden and Botanical Museum Berlin-Dahlem & Hellenic Botanical Society.
16. Dimopoulos, P., Raus, T., Bergmeier, E., Constantinidis, T., Iatrou, G., Kokkini, S., Strid, A., & Tzanoudakis, D. (2016). *Vascular plants of Greece: An annotated checklist. Supplement*. *Willdenowia*, 46(3), 301–347. https://doi.org/10.3372/wi.46.46303
17. Dobros, N., Zawada, K. D., & Paradowska, K. (2022). Phytochemical profiling, antioxidant, and anti-inflammatory activity of plants belonging to the *Lavandula* genus. *Molecules*, 28(1), 256. https://doi.org/10.3390/molecules28010256
18. Erenler, R., Meral, B., Sen, O., Elmastaş, M., Aydın, A., Eminagaoglu, O., & Topcu, G. (2017). Bioassay-guided isolation, identification of compounds from *Origanum rotundifolium* and investigation of their antiproliferative and antioxidant activities. *Pharmaceutical Biology*, 55(1), 1646-1653. https://doi.org/10.1080/13880209.2017.1310906
19. Gaya, M., Repetto, V., Toneatto, J., Anesini, C., & Piwien-Pilipuk, G. (2013). Antiadipogenic effect of carnosic acid, a natural compound present in *Rosmarinus officinalis*, is exerted through the C/EBPs and PPARγ pathways at the onset of the differentiation program. *Biochimica et Biophysica Acta (BBA) - General Subjects*, 1830(6), 3796-3806.
20. Gonçalves, C., Fernandes, D., Silva, I., & Mateus, V. (2022). Potential anti-inflammatory effect of *Rosmarinus officinalis* in preclinical in vivo models of inflammation. *Molecules*, 27(3), 609. https://doi.org/10.3390/molecules27030609
21. Gutiérrez, R., Jerónimo, F., Soto, J., Ramírez, A., & Mendoza, M. (2021). Optimization of ultrasonic-assisted extraction of polyphenols from the polyherbal formulation of *Cinnamomum verum*, *Origanum majorana*, and *Origanum vulgare* and their anti-diabetic capacity in zebrafish (*Danio rerio*). *Heliyon*, 8(1), e08682. https://doi.org/10.1016/j.heliyon.2021.e08682
22. Habán, M., Korczyk-Szabó, J., Certekov, S., & Ražná, K. (2023). *Lavandula* species, their bioactive phytochemicals, and their biosynthetic regulation. *International Journal of Molecular Sciences*, 24, 8831. https://doi.org/10.3390/ijms24108831
23. Hajhashemi, V., Ghannadi, A., & Sharif, B. (2023). Anti-inflammatory and analgesic properties of the leaf extracts and essential oil of *Lavandula angustifolia* Mill. *Journal of Ethnopharmacology*, 89(1), 67-71. https://doi.org/10.1016/s0378-8741(03)00234-4
24. Issa, A., Mohammad, M., Hudaib, M., & Bustanji, Y. (2011). A potential role of *Lavandula angustifolia* in the management of diabetic dyslipidemia. *Journal of Medicinal Plants Research*, 5(16), 3876-3882.
25. Khalil, O. A., Ramadan, K. S., Danial, E. N., Alnahdi, H. S., & Ayaz, N. O. (2012). Antidiabetic activity of *Rosmarinus officinalis* and its relationship with the antioxidant property. *African Journal of Pharmacy and Pharmacology*, 6(14), 1031-1036.
26. Khnissi, S., Bomboi, G., Khémiri, I., Ben Salem, I., Dattena, M., Sai, S., Ben Mustapha, S., Cabiddu, A., & Lassoued, N. (2023). Incorporation of fresh leaves of wormwood (*Artemisia herba-alba*) and/or rosemary (*Rosmarinus officinalis*) in the diet of rams: Effect on testicular function, sexual behavior, and blood parameters. *Food Science & Nutrition*, 11(6), 3121-3130. https://doi.org/10.1002/fsn3.3293
27. Koycheva, I., Vasileva, L., Amirova, K., Marchev, A., Balcheva-Sivenova, Z., & Georgiev, M. (2021). Biotechnologically produced *Lavandula angustifolia* Mill. extract rich in rosmarinic acid resolves psoriasis-related inflammation through Janus kinase/signal transducer and activator of transcription signaling. *Frontiers in Pharmacology*, 12, 680168. https://doi.org/10.3389/fphar.2021.680168
28. Lari, Z., Hajimonfarednejad, M., Riasatian, M., Abolhassanzadeh, Z., Iraji, A., Vojoud, M., Heydari, M., & Shams, M. (2020). Efficacy of inhaled *Lavandula angustifolia* Mill. essential oil on sleep quality, quality of life, and metabolic control in patients with diabetes mellitus type II and insomnia. *Journal of Ethnopharmacology*, 251, 112560. https://doi.org/10.1016/j.jep.2020.112560
29. Letsiou, S., Trapali, M., Tebbi, S. O., & Benaida-Debbache, N. (2023). A simple and robust LC-ESI single quadrupole MS-based method to analyze polyphenols in plant extracts using deep eutectic solvents. *MethodsX*, 11, 102303.
30. Letsiou, S., Trapali, M., Vougiouklaki, D., Tsakni, A., Antonopoulos, D., & Houhoula, D. (2023). Antioxidant profile of *Origanum dictamnus* L. exhibits antiaging properties against UVA irradiation. *Cosmetics*, 10(5), 124. https://doi.org/10.3390/cosmetics10050124
31. Leyva-Lopez, N., Gutiérrez-Grijalva, E. P., Vazquez-Olivo, G., & Heredia, J. B. (2017). Essential oils of oregano: Biological activity beyond their antimicrobial properties. *Molecules*, 22(6), 989. https://doi.org/10.3390/molecules22060989
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Published
2024-10-31
How to Cite
Lagouri, V., Tebbi, S. O., Caseiro, A., & Trapali, M. (2024). Lamiaceae Family Plants as Natural Solutions for Inflammation and Blood Sugar Management. European Scientific Journal, ESJ, 20(30), 34. https://doi.org/10.19044/esj.2024.v20n30p34
Section
ESJ Natural/Life/Medical Sciences
Copyright (c) 2024 Vasiliki Lagouri, Sara Oumenoune Tebbi, Armando Caseiro, Maria Trapali
This work is licensed under a Creative Commons Attribution 4.0 International License.
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